手性有机催化的硝基烯烃与丙二烯酸乙酯的分子间劳乌特-库里尔反应
Chiral Organocatalyzed Intermolecular Rauhut-Currier Reaction of Nitroalkenes with Ethyl Allenoate.
作者信息
Takizawa Shinobu, Sako Makoto, Kishi Kenta, Shigenobu Masashi, Vo-Thanh Giang, Sasai Hiroaki
机构信息
The Institute of Scientific and Industrial Research (ISIR), Osaka University.
Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), UMR8182. Laboratoire de Catalyse Moléculaire, Université Paris-Sud, Université Paris Saclay.
出版信息
Chem Pharm Bull (Tokyo). 2017;65(11):997-999. doi: 10.1248/cpb.c17-00554.
An enantioselective intermolecular Rauhut-Currier (RC) reaction of nitroalkenes with ethyl allenoate has been established with quinidine-derived β-isocupreidine. The present RC reaction afforded α-functionalized allenoates 3 in up to 94% yield with 59% enantiomeric excess (ee).
已利用奎尼丁衍生的β-异铜试剂实现了硝基烯烃与丙烯酸乙酯的对映选择性分子间劳乌特-柯里尔（RC）反应。目前的RC反应以高达94%的产率和59%的对映体过量（ee）得到了α-官能化丙烯酸酯3。
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