通过主客体相互作用构建的完全基于寡糖的超分子两亲物作为高效药物递送平台。
Entirely oligosaccharide-based supramolecular amphiphiles constructed via host-guest interactions as efficient drug delivery platforms.
作者信息
Shi Yuting, Li Hongping, Cheng Ju, Luan Tingting, Liu Di, Cao Yufei, Zhang Xiangdong, Wei Hua, Liu Yali, Zhao Guanghui
机构信息
State Key Laboratory of Applied Organic Chemistry, Institute of Biochemical Engineering & Environmental Technology, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
出版信息
Chem Commun (Camb). 2017 Nov 14;53(91):12302-12305. doi: 10.1039/c7cc06553a.
Entirely oligosaccharide-based supramolecular amphiphiles were constructed via host-guest interactions between ferrocene-terminated acetylated-maltoheptaose (Fc-AcMH) and β-cyclodextrin-terminated four-arm star maltoheptaose (MH-β-CD). The amphiphiles could self-assemble to form spherical supramolecular nanoparticles to provide efficient drug delivery platforms. The combination of a pH-sensitive covalent acetal group and the oxidation-sensitive noncovalent host-guest interaction of β-CD and ferrocene provided the obtained fully oligosaccharide-based supramolecular amphiphiles. The structures of these amphiphiles could respond to the intracellular microenvironment.
通过二茂铁封端的乙酰化麦芽七糖（Fc-AcMH）与β-环糊精封端的四臂星形麦芽七糖（MH-β-CD）之间的主客体相互作用构建了完全基于寡糖的超分子两亲物。这些两亲物能够自组装形成球形超分子纳米颗粒，以提供高效的药物递送平台。pH敏感的共价缩醛基团与β-环糊精和二茂铁的氧化敏感非共价主客体相互作用相结合，得到了完全基于寡糖的超分子两亲物。这些两亲物的结构能够对细胞内微环境做出响应。
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