Li Yilin, Su Yuteng, Li Zhaoxiang, Chen Yueyue
Department of Toxicology and Sanitary Chemistry, School of Public Health, Beijing Key Laboratory of Environment Toxicology, Capital Medical University, Beijing 100069, China.
Polymers (Basel). 2022 Nov 11;14(22):4855. doi: 10.3390/polym14224855.
Supramolecular combination therapy adopts supramolecular materials to design intelligent drug delivery systems with different strategies for cancer treatments. Thereinto, macrocyclic supramolecular materials play a crucial role in encapsulating anticancer drugs to improve anticancer efficiency and decrease toxicity towards normal tissue by host-guest interaction. In general, chemotherapy is still common therapy for solid tumors in clinics. However, supramolecular combination therapy can overcome the limitations of the traditional single-drug chemotherapy in the laboratory findings. In this review, we summarized the combination chemotherapy, photothermal chemotherapy, and gene chemotherapy based on macrocyclic supramolecular materials. Finally, the application prospects in supramolecular combination therapy are discussed.
超分子联合疗法采用超分子材料，通过不同策略设计用于癌症治疗的智能药物递送系统。其中，大环超分子材料在通过主客体相互作用包封抗癌药物以提高抗癌效率并降低对正常组织的毒性方面发挥着关键作用。一般来说，化疗仍是临床上治疗实体瘤的常用方法。然而，超分子联合疗法在实验室研究结果中能够克服传统单药化疗的局限性。在本综述中，我们总结了基于大环超分子材料的联合化疗、光热化疗和基因化疗。最后，讨论了超分子联合疗法的应用前景。
