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红花、橄榄油及其他植物油复方用于改善瘢痕和妊娠纹外观的观察者盲法随机对照研究

Observer-blind randomized controlled study of a cosmetic blend of safflower, olive and other plant oils in the improvement of scar and striae appearance.

作者信息

Bielfeldt S, Blaak J, Staib P, Simon I, Wohlfart R, Manger C, Wilhelm K P

机构信息

proDERM, Institute for Applied Dermatological Research GmbH, Kiebitzweg 2, Schenefeld/Hamburg, DE 22869, Germany.

Kneipp GmbH, Research & Development, Winterhäuser Str. 85, Würzburg, DE 97084, Germany.

出版信息

Int J Cosmet Sci. 2018 Feb;40(1):81-86. doi: 10.1111/ics.12438. Epub 2017 Dec 12.

Abstract

OBJECTIVE

The normal process of skin tissue repair following injury invariably results in visual scarring. It is known that topical treatment with hydrophobic cosmetics rich in silicone and mineral oil content can improve the appearance of scars and striae. Given lifestyle preferences of many cosmetic consumers towards so-called natural treatments, the objective of this controlled randomized study was to investigate the efficacy of a plant body oil rich in oleic and linoleic acids (Bio Skin Oil ) for improving the appearance of scars and striae.

METHODS

A panel of 80 volunteers with non-hypertrophic scars (40) or stretch marks (40) not older than 3 years applied a cosmetic face and body oil for 8 weeks. Compared to an untreated scar/stretch mark region, a blinded investigator as well as volunteer assessments with given observed parameters demonstrated the efficacy of the oil under test.

RESULTS

On the Observer Scar Assessment Scale (OSAS), the mean score was reduced on the product-treated area by approximately 5% (P = 0.006). The untreated area remained unchanged. Observed effects by volunteers were more pronounced - Patient Scar Assessment Scale (PSAS) giving a reduction of approximately 20% on the treated area, and on the control untreated area a reduction of approximately 6%. The overall product effect of 14% was shown to be clearly significant (P = 0.001). All statements relating to product traits achieved higher frequencies of agreements than of non-agreements and were therefore assessed positively by the volunteers. Highest frequencies of agreements occurred in statements that the test product provides a long-lasting, soft and supple skin feeling (93%); caring effect (87%); and quick absorbance (84%). Agreement was also found for statements that the product improves the skin appearance (61%) and that scars/striae appear less pronounced (51%). Only 17% of volunteers felt the oil had no benefit to the appearance of their scars/striae.

CONCLUSIONS

The oil blend under test is effective in improving the appearance of non-keloid scars and striae. Further work is required to understand the mechanisms of how plant oil fatty acids ameliorate scar and striae appearance.

摘要

目的

皮肤组织损伤后的正常修复过程总会导致明显的瘢痕形成。已知使用富含硅酮和矿物油的疏水性化妆品进行局部治疗可改善瘢痕和妊娠纹的外观。鉴于许多化妆品消费者对所谓天然疗法的生活方式偏好,本对照随机研究的目的是调查富含油酸和亚油酸的植物身体油(生物皮肤油)改善瘢痕和妊娠纹外观的疗效。

方法

80名志愿者组成的小组,他们有不超过3年的非肥厚性瘢痕(40例)或妊娠纹(40例),使用一种面部和身体化妆品油8周。与未治疗的瘢痕/妊娠纹区域相比,一名盲法研究者以及志愿者根据给定的观察参数进行的评估证明了受试油的疗效。

结果

在观察者瘢痕评估量表(OSAS)上,产品治疗区域的平均得分降低了约5%(P = 0.006)。未治疗区域保持不变。志愿者观察到的效果更明显——患者瘢痕评估量表(PSAS)显示治疗区域降低了约20%,而对照未治疗区域降低了约6%。14%的总体产品效果显示具有明显显著性(P = 0.001)。所有与产品特性相关的陈述达成一致的频率高于未达成一致的频率,因此得到志愿者的积极评价。达成一致频率最高的陈述是受试产品能提供持久、柔软和顺滑的皮肤感觉(93%);护理效果(87%);以及快速吸收(84%)。对于产品改善皮肤外观(61%)以及瘢痕/妊娠纹看起来不那么明显(51%)的陈述也达成了一致。只有17%的志愿者认为该油对其瘢痕/妊娠纹的外观没有益处。

结论

受试油混合物在改善非瘢痕疙瘩性瘢痕和妊娠纹的外观方面是有效的。需要进一步开展工作以了解植物油脂肪酸改善瘢痕和妊娠纹外观的机制。

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