1 型糖尿病的遗传学。
Genetics of type 1 diabetes.
机构信息
Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado.
出版信息
Pediatr Diabetes. 2018 May;19(3):346-353. doi: 10.1111/pedi.12597. Epub 2017 Nov 2.
Abstract
Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.
摘要
1 型糖尿病（T1D）是由胰腺β细胞的免疫介导性丧失导致胰岛素缺乏引起的。它是儿童中最常见的糖尿病形式，其发病率呈上升趋势。本文综述了 T1D 的遗传学研究现状。特别地，我们讨论了 HLA 和非 HLA 基因通过疾病的临床前阶段对 T1D 风险和疾病进展的影响，以及可应用于疾病预测的遗传评分的发展。还讨论了 T1D 遗传学中的种族/民族差异、挑战和未来方向。
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UBASH3A Mediates Risk for Type 1 Diabetes Through Inhibition of T-Cell Receptor-Induced NF-κB Signaling.UBASH3A通过抑制T细胞受体诱导的NF-κB信号传导介导1型糖尿病风险。
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