De Carvalho Barbara Fernandes, Policarpo Sara, Moreira Ana Catarina
Faculdade de Medicina da Universidade de Lisboa in association with Escola Superior de Tecnologia da Saúde de Lisboa.
Nutr Hosp. 2017 Jul 28;34(4):923-933. doi: 10.20960/nh.453.
Nutritional status and the progression of the human immunodeficiency virus (HIV) are interlinked; though some studies have looked at the impact nutritional status has on quality of life (QoL) in patients with chronic diseases, few have studied this in HIV-infected individuals.
To investigate the relationship between nutritional status and QoL in adults with a recent HIV diagnosis.
Individuals with an HIV diagnosis performed in the fourteen months prior to a medical visit to one of Lisbon's central hospitals were eligible. Nutritional status was assessed by anthropometry, body composition analysis, and dietary intake. QoL was assessed using the WHOQOLHIV-BREF questionnaire. Sociodemographic and clinical data were also considered.
Fifty-one subjects were eligible for enrolment; the majority were male, Caucasian, employed, single, and under highly active antiretroviral therapy (HAART). Lower QoL scores were observed in subjects with inadequate energy intakes, reported weight loss, and a high waist circumference in bivariate analysis (p < 0.05); the same variables influenced QoL negatively after adjusting for confounders in multivariate analysis (p < 0.05). Various sociodemographic characteristics such as level of education, age, gender, and current health problems also predicted QoL significantly (p < 0.05).
Various aspects of nutritional status were responsible for the variations observed in QoL, suggesting a potential for nutritional intervention in improving QoL in this population.
营养状况与人类免疫缺陷病毒（HIV）的病情进展相互关联；尽管一些研究探讨了营养状况对慢性病患者生活质量（QoL）的影响，但很少有研究针对HIV感染者进行此项研究。
调查近期诊断为HIV的成年人营养状况与生活质量之间的关系。
在前往里斯本一家中心医院就诊前14个月内被诊断为HIV的个体符合条件。通过人体测量、身体成分分析和饮食摄入量评估营养状况。使用WHOQOLHIV-BREF问卷评估生活质量。还考虑了社会人口统计学和临床数据。
51名受试者符合纳入条件；大多数为男性、白种人、有工作、单身且正在接受高效抗逆转录病毒治疗（HAART）。在双变量分析中，能量摄入不足、报告有体重减轻和腰围较大的受试者生活质量得分较低（p < 0.05）；在多变量分析中对混杂因素进行调整后，相同变量对生活质量有负面影响（p < 0.05）。各种社会人口统计学特征，如教育水平、年龄、性别和当前健康问题，也对生活质量有显著预测作用（p < 0.05）。
营养状况的各个方面导致了生活质量的差异，这表明在该人群中进行营养干预以改善生活质量具有潜力。
