a Department of Pharmacology and Toxicology , Michigan State University , East Lansing , MI , USA.
Adipocyte. 2018 Jan 2;7(1):45-48. doi: 10.1080/21623945.2017.1388971. Epub 2017 Nov 2.
Although there is a growing number of incidences of obesity and obesity-linked cancers, how excess adiposity actually causes cancer has not been fully explained. Our previous study showed that removal of visceral adipose tissue significantly reduced the number of ultraviolet radiation (UVR)-initiated, high-fat diet-promoted skin cancers. This commentary focuses on our recently published study (Chakraborty, et al., 2017) which demonstrated that fibroblast growth factor-2 (FGF2) released from visceral adipose tissue is a key factor in the malignant transformation of epithelial cells. Within this commentary we have provided additional interpretations and new data in support of the role of FGF2 in adiposity-associated tumorigenesis.
尽管肥胖和肥胖相关癌症的发病率不断上升，但过多的体脂是如何导致癌症的仍未得到充分解释。我们之前的研究表明，去除内脏脂肪组织可显著减少紫外线（UVR）引发、高脂肪饮食促进的皮肤癌的数量。本评论重点介绍了我们最近发表的一项研究（Chakraborty 等人，2017 年），该研究表明，来自内脏脂肪组织的成纤维细胞生长因子 2（FGF2）是上皮细胞恶性转化的关键因素。在本评论中，我们提供了更多的解释和新的数据，以支持 FGF2 在肥胖相关肿瘤发生中的作用。
