Schernthaner Christiana, Paar Vera, Wernly Bernhard, Pistulli Rudin, Rohm Ilonka, Jung Christian, Figulla Hans-Reiner, Yilmaz Attila, Cadamuro Janne, Haschke-Becher Elisabeth, Schulze P Christian, Hoppe Uta C, Lichtenauer Michael, Kretzschmar Daniel
Department of Cardiology, Paracelsus Medical University, Salzburg, Austria Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology and Intensive MedicalCare, Friedrich-Schiller-University Jena, Jena, Germany Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
Medicine (Baltimore). 2017 Nov;96(44):e8396. doi: 10.1097/MD.0000000000008396.
Interleukin (IL)-16, a polypeptide cytokine, plays a crucial role in the inflammatory process, acting as a chemoattractant for peripheral immune cells and has been linked to various inflammatory diseases. However, its role in patients with acute myocardial infarction (AMI) is unclear.We retrospectively analyzed serum levels of IL-16 in blood of patients with (STEMI, n = 45) and without ST-segment elevation myocardial infarction (NSTEMI, n = 42) compared with controls with excluded coronary artery disease (n = 55). Furthermore, correlation analysis with inflammatory cells, C-reactive protein (CRP) levels, dendritic cell precursors (DCPs), and other clinical and biochemical markers was performed.Compared with controls, patients with STEMI and NSTEMI evidenced higher levels of IL-16 in pg/mL (STEMI: 759.38 ± 471.54, NSTEMI: 677.77 ± 438.8, control: 500.45 ± 432.21; P = .002). IL-16 correlated with CRP (r = 0.26, P = .001), leucocytes (r = 0.38, P < .001), NT-proBNP (r = 0.20, P = .02) and hsTnT (r = 0.25, P = .004). Circulating myeloid DCPs, plasmacytoid DCPs, and total DCPs showed a significant inverse correlation to IL-16 levels (r = -0.21, P = .01; r = -0.23, P = .005; r = -0.26, P = .002, respectively).Interleukin-16 might play an important role in the inflammatory process of patients suffering from AMI and correlates with inflammatory cell activation and clinical and biochemical markers. The cytokine IL-16 might upregulate the proinflammatory response and recruitment of inflammatory cells into infarcted myocardium.
白细胞介素（IL）-16是一种多肽细胞因子，在炎症过程中起关键作用，作为外周免疫细胞的趋化因子，与多种炎症性疾病有关。然而，其在急性心肌梗死（AMI）患者中的作用尚不清楚。我们回顾性分析了45例ST段抬高型心肌梗死（STEMI）患者和42例非ST段抬高型心肌梗死（NSTEMI）患者血液中IL-16的血清水平，并与排除冠状动脉疾病的55例对照者进行比较。此外，还进行了与炎症细胞、C反应蛋白（CRP）水平、树突状细胞前体（DCP）以及其他临床和生化标志物的相关性分析。与对照组相比，STEMI和NSTEMI患者的IL-16水平以pg/mL计更高（STEMI：759.38±471.54，NSTEMI：677.77±438.8，对照组：500.45±432.21；P = 0.002）。IL-16与CRP（r = 0.26，P = 0.001）、白细胞（r = 0.38，P < 0.001）、NT-proBNP（r = 0.20，P = 0.02）和hsTnT（r = 0.25，P = 0.004）相关。循环中的髓样DCP、浆细胞样DCP和总DCP与IL-16水平呈显著负相关（分别为r = -0.21，P = 0.01；r = -0.23，P = 0.005；r = -0.26，P = 0.002）。白细胞介素-16可能在AMI患者的炎症过程中起重要作用，并与炎症细胞活化以及临床和生化标志物相关。细胞因子IL-16可能上调促炎反应并将炎症细胞募集到梗死心肌中。
