School of Chemistry and Analytical and Biological Chemistry Research Facility, University College Cork, College Road, Cork, Ireland.
Org Biomol Chem. 2018 Jan 3;16(2):169-179. doi: 10.1039/c7ob02395b.
The emergence of antibiotic resistance coupled with the lack of investment by pharmaceutical companies necessitates a new look at how we tackle bacterial infections. An intriguing tactic is the interruption of bacterial communication systems. This non-biocidal approach would circumvent the evolutionary pressure on bacteria to mutate and develop resistance. In many pathogenic microorganisms, communication systems, collectively termed quorum sensing (QS), have been observed to control a number of bacterial behaviours including expression of virulence factors and the development of biofilms. QS signalling molecules and their biomimetics, therefore, represent a rational target for the disruption of cooperative behaviour and thus the development of novel antimicrobial strategies. Herein we review recent developments towards the interference of Pseudomonas aeruginosa QS using signalling molecules and their mimetics.
抗生素耐药性的出现加上制药公司投资不足，使得我们需要重新审视如何应对细菌感染。一种有趣的策略是中断细菌的通讯系统。这种非杀菌方法可以避免细菌因进化而突变和产生耐药性的压力。在许多致病性微生物中，已经观察到通讯系统（统称为群体感应 (QS)）控制着许多细菌行为，包括毒力因子的表达和生物膜的形成。因此，QS 信号分子及其类似物是破坏合作行为并开发新型抗菌策略的合理靶标。本文综述了近年来使用信号分子及其类似物干扰铜绿假单胞菌 QS 的最新进展。
