Antwis Rachael Ellen, Weldon Ché
School of Environment and Life Sciences, University of Salford, Salford, UK.
Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa.
Microbiology (Reading). 2017 Dec;163(12):1835-1838. doi: 10.1099/mic.0.000570.
The fungal pathogen has caused declines and extinctions in hundreds of amphibian species across the world. Virulence varies among and within lineages; the Global Panzootic Lineage (GPL) is the most pathogenic, although there is also variation in lethality among GPL isolates. Amphibians have a number of defences against pathogens, and skin products including the microbiota and host peptides have considerable influence over disease progression. Here we demonstrate that the collective skin products (the mucosome) of two amphibian species show significant variation in their ability to inhibit different globally distributed isolates of GPL. This may in part explain the variation in disease susceptibility of hosts to different strains of . More work is required to identify particular traits associated with mucosomes that confer broad-spectrum inhibition across GPL in order to facilitate the development of prophylaxis and/or treatments for chytridiomycosis .
这种真菌病原体已导致全球数百种两栖动物物种数量减少和灭绝。毒力在谱系之间和谱系内部存在差异；全球泛动物谱系（GPL）致病性最强，不过GPL分离株之间的致死率也存在差异。两栖动物对病原体有多种防御机制，包括微生物群和宿主肽在内的皮肤产物对疾病进展有相当大的影响。在这里，我们证明两种两栖动物物种的集体皮肤产物（黏液体）在抑制不同全球分布的GPL分离株的能力上存在显著差异。这可能部分解释了宿主对不同菌株疾病易感性的差异。需要开展更多工作来确定与黏液体相关的特定特征，这些特征能对GPL产生广谱抑制作用，以便促进蛙壶菌病预防和/或治疗方法的开发。
