Department of Cardiology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
J Clin Endocrinol Metab. 2018 Jan 1;103(1):12-15. doi: 10.1210/jc.2017-01117.
Catecholamine-related factors are the most popular explanation for the occurrence of Takotsubo syndrome. An aldosterone-related mechanism, however, has not been proposed.
A 45-year-old male patient presenting with ST-segment elevation myocardial infarction was diagnosed with primary aldosteronism, severe hypokalemia, and Takotsubo syndrome. After excluding the known conditions of apical ballooning and the factors of vasospasm, primary aldosteronism is considered as the major contributor to the development of Takotsubo syndrome. The potential mechanisms are discussed.
The case suggests a possible hyperaldosteronism-induced and vasoconstriction-mediated mechanism in the development of Takotsubo syndrome.
儿茶酚胺相关因素是 Takotsubo 综合征发生的最常见解释。然而，醛固酮相关机制尚未提出。
一名 45 岁男性患者因 ST 段抬高型心肌梗死就诊，被诊断为原发性醛固酮增多症、严重低钾血症和 Takotsubo 综合征。排除已知的尖顶球囊样改变和血管痉挛因素后，原发性醛固酮增多症被认为是 Takotsubo 综合征发展的主要原因。讨论了潜在的机制。
该病例提示 Takotsubo 综合征的发生可能与高醛固酮血症诱导的血管收缩有关。
