一种人血清甘露糖结合蛋白可抑制人免疫缺陷病毒的体外感染。
A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus.
作者信息
Ezekowitz R A, Kuhlman M, Groopman J E, Byrn R A
机构信息
Division of Hematology/Oncology, Harvard Medical School, Boston, Massachusetts.
出版信息
J Exp Med. 1989 Jan 1;169(1):185-96. doi: 10.1084/jem.169.1.185.
Abstract
In vitro infection by the human immunodeficiency virus (HIV) of CD4+ H9 lymphoblasts is inhibited by a mannose-binding protein (MBP) purified from human serum. In addition, MBP is able to selectively bind to HIV-infected H9 cells and HIV-infected cells from the monocyte cell line U937. These results indicate MBP most likely recognizes high mannose glycans known to be present on gp120 in the domain that is recognized by CD4 and thereby inhibits viral entry to susceptible cells. In support of this contention, recombinant gp120 binds directly to MBP; the binding is saturable, mannan inhibitable, removed by N-glycanase treatment, and dependent on divalent cations.
摘要
从人血清中纯化出的甘露糖结合蛋白（MBP）可抑制人免疫缺陷病毒（HIV）对CD4⁺ H9淋巴母细胞的体外感染。此外，MBP能够选择性地结合HIV感染的H9细胞以及单核细胞系U937中的HIV感染细胞。这些结果表明，MBP很可能识别CD4识别区域中已知存在于gp120上的高甘露糖聚糖，从而抑制病毒进入易感细胞。为支持这一论点，重组gp120可直接与MBP结合；这种结合具有饱和性、可被甘露聚糖抑制、经N - 糖苷酶处理后可去除，且依赖于二价阳离子。
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