Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu, 212013, China.
Institute of Digestive Diseases, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212002, China.
J Exp Clin Cancer Res. 2017 Nov 2;36(1):152. doi: 10.1186/s13046-017-0624-z.
CircRNAs are a class of RNA molecules that structurally form closed loops. CircRNAs are abundant in eukaryotic transcripts and show certain levels of tissue and cell specificity. CircRNAs have been suggested to regulate gene expression at transcriptional, post-transcriptional, and translational levels. An increasing number of studies have shown that circRNAs play important roles in the development and progression of diseases including cancer. In particular, circRNAs have shown great potential in cancer diagnosis, prognosis, and therapy. In this review, we provide an overview of the biogenesis and characteristics of circRNAs, succinctly describe their functions, and comprehensively discuss about the recent advances in the roles of circRNAs in cancer with an emphasis on their clinical values.
CircRNAs 是一类结构上形成封闭环的 RNA 分子。CircRNAs 在真核转录物中丰富，并表现出一定程度的组织和细胞特异性。CircRNAs 被认为可以在转录、转录后和翻译水平上调节基因表达。越来越多的研究表明，CircRNAs 在包括癌症在内的疾病的发生和发展中发挥着重要作用。特别是，CircRNAs 在癌症诊断、预后和治疗方面显示出巨大的潜力。在这篇综述中，我们提供了 CircRNAs 的生物发生和特征概述，简洁地描述了它们的功能，并全面讨论了 CircRNAs 在癌症中的作用的最新进展，重点介绍了它们的临床价值。
