Wu J-P, Luo X
Department of Obstetrics and gynaecology, Guangzhou Huadu Maternal and Children Healthcare Hospital, Guangzhou 510800, Guangdong, China.
Cell Mol Biol (Noisy-le-grand). 2017 Oct 31;63(10):128-130. doi: 10.14715/cmb/2017.63.10.20.
Some studies investigated the association between the murine double minute 2 (MDM2) rs2279744 polymorphism and endometrial cancer susceptibility, but provided controversial or inconclusive results. Thus, we decided to perform this case-control study to determine the association between MDM2 rs2279744 polymorphism and endometrial cancer in a Chinese Han population. A total of 215 endometrial cancer patients and 212 cancer-free controls were included in this case-control study. We genotyped the MDM2 rs2279744 polymorphism by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). GG genotype showed a statistically significantly increased risk of developing endometrial cancer (OR=1.72, 95%CI 1.08-2.76, P=0.02). Statistically significant difference was observed when the patients and controls were compared according to G versus I (OR=1.40, 95%CI 1.07-1.84, P=0.01). A significantly higher frequency of G allele was observed in patients with stage III+IV, compared to stage I+II (OR=2.24, 95%CI 1.49-3.38, P=0.001). In conclusion, the study found that MDM2 rs2279744 polymorphism was significantly associated with endometrial cancer risk in a Chinese Han population.
一些研究调查了鼠双微体2（MDM2）rs2279744多态性与子宫内膜癌易感性之间的关联，但结果存在争议或尚无定论。因此，我们决定开展这项病例对照研究，以确定中国汉族人群中MDM2 rs2279744多态性与子宫内膜癌之间的关联。这项病例对照研究共纳入了215例子宫内膜癌患者和212例无癌对照。我们采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对MDM2 rs2279744多态性进行基因分型。GG基因型显示患子宫内膜癌的风险在统计学上显著增加（OR=1.72，95%CI 1.08-2.76，P=0.02）。当根据G与I对患者和对照进行比较时，观察到统计学上的显著差异（OR=1.40，95%CI 1.07-1.84，P=0.01）。与I+II期相比，III+IV期患者中G等位基因的频率显著更高（OR=2.24，95%CI 1.49-3.38，P=0.001）。总之，该研究发现MDM2 rs2279744多态性与中国汉族人群的子宫内膜癌风险显著相关。
