鼠双微体 2 基因型与肺癌风险的关联。
Association of Murine Double Minute 2 Genotypes and Lung Cancer Risk.
机构信息
Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
出版信息
In Vivo. 2020 May-Jun;34(3):1047-1052. doi: 10.21873/invivo.11874.
AIM
The aim of this study was to evaluate the contribution of human mouse double minute 2 (MDM2) gene polymorphisms to the risk of Taiwan lung cancer.
MATERIALS AND METHODS
In this case-control study, the association of MDM2 rs2279744 genotypes with lung cancer risk was investigated among 358 lung cancer patients and 716 age-, gender- and smoking status-matched controls in Taiwan.
RESULTS
The percentages of MDM2 rs2279744 GT and GG genotypes were 50.0% and 27.4% in lung cancer group and 50.0% and 26.5% in control group, respectively [odds ratio (OR)=1.03 and 1.07, 95% confidence interval (CI)=0.75-1.43 and 0.75-1.53, respectively]. The analysis about allelic frequency showed that G allele at MDM2 rs2279744 conferred a non-significant increased cancer risk (OR=1.03, 95%CI=0.86-1.24).
CONCLUSION
Polymorphisms of MDM2 rs2279744 may play a role in lung carcinogenesis. However, the studied genotypes were not shown as predictors of lung cancer susceptibility.
目的
本研究旨在评估人鼠双微基因 2（MDM2）基因多态性对台湾地区肺癌发病风险的影响。
材料与方法
在这项病例对照研究中，研究了 MDM2 rs2279744 基因型与台湾 358 例肺癌患者和 716 例年龄、性别和吸烟状况匹配对照者肺癌风险的相关性。
结果
肺癌组和对照组 MDM2 rs2279744 GT 和 GG 基因型的百分比分别为 50.0%和 27.4%，以及 50.0%和 26.5%[比值比（OR）=1.03 和 1.07，95%置信区间（CI）=0.75-1.43 和 0.75-1.53]。等位基因频率分析表明，MDM2 rs2279744 处的 G 等位基因赋予非显著增加的癌症风险（OR=1.03，95%CI=0.86-1.24）。
结论
MDM2 rs2279744 多态性可能在肺癌发生中起作用。然而，所研究的基因型并未显示为肺癌易感性的预测因子。
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