白种人中ALOX5AP基因rs10507391多态性与缺血性中风风险：一项更新的荟萃分析。
ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians: an update meta-analysis.
作者信息
Li K-L, Chen C-Y, Xu M, Zhu X-Q, Yang X-J
机构信息
Department of Neurology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China.
Department of Internal Medicine, Shanghai Electric Power Hospital, Shanghai 200050, China.
出版信息
Cell Mol Biol (Noisy-le-grand). 2017 Oct 31;63(10):137-140. doi: 10.14715/cmb/2017.63.10.22.
Some reports evaluated the association between ALOX5AP rs10507391 polymorphism and the risk of ischemic stroke in Caucasians. The results remained unknown. Thus, we did a meta-analysis to evaluate this association. Nine case-control studies with 4198 patients and 3699 controls were included in this meta-analysis. A significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in Caucasians (OR=1.18; 95%CI, 1.08-1.28; P=0.0002). ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians from Europe (OR=1.20; 95%CI, 1.09-1.32; P=0.0002) but not from other countries (OR=1.13; 95%CI, 0.95-1.36; P=0.17). No significant association was found between ALOX5AP rs10507391 polymorphism and ischemic stroke risk in males (OR=1.12; 95%CI, 0.91-1.39; P=0.28). Moreover, ALOX5AP rs10507391 polymorphism was not associated with cardioembolic ischemic stroke risk (OR=1.04; 95%CI, 0.73-1.48; P=0.84). In conclusion, this study found that ALOX5AP rs10507391 polymorphism was associated with ischemic stroke risk in Caucasians.
一些报告评估了白种人中5-脂氧合酶激活蛋白（ALOX5AP）基因rs10507391多态性与缺血性中风风险之间的关联。结果尚不清楚。因此，我们进行了一项荟萃分析来评估这种关联。该荟萃分析纳入了9项病例对照研究，共4198例患者和3699例对照。研究发现，白种人中ALOX5AP基因rs10507391多态性与缺血性中风风险之间存在显著关联（比值比[OR]=1.18；95%置信区间[CI]为1.08 - 1.28；P=0.0002）。ALOX5AP基因rs10507391多态性与欧洲白种人的缺血性中风风险相关（OR=1.20；95%CI为1.09 - 1.32；P=0.0002），但与其他国家白种人的缺血性中风风险无关（OR=1.13；95%CI为0.95 - 1.36；P=0.17）。在男性中，未发现ALOX5AP基因rs10507391多态性与缺血性中风风险之间存在显著关联（OR=1.12；95%CI为0.91 - 1.39；P=0.28）。此外，ALOX5AP基因rs10507391多态性与心源性栓塞性缺血性中风风险无关（OR=1.04；95%CI为0.73 - 1.48；P=0.84）。总之，本研究发现ALOX5AP基因rs10507391多态性与白种人的缺血性中风风险相关。
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