Department of Nursing, Ryazan State Medical University, 390026 Ryazan, Russia.
Genes (Basel). 2022 Aug 18;13(8):1474. doi: 10.3390/genes13081474.
Atherosclerosis is one of the most important medical and social problems of modern society. Atherosclerosis causes a large number of hospitalizations, disability, and mortality. A considerable amount of evidence suggests that inflammation is one of the key links in the pathogenesis of atherosclerosis. Inflammation in the vascular wall has extensive cross-linkages with lipid metabolism, and lipid mediators act as a central link in the regulation of inflammation in the vascular wall. Data on the role of genetics and epigenetic factors in the development of atherosclerosis are of great interest. A growing body of evidence is strengthening the understanding of the significance of gene polymorphism, as well as gene expression dysregulation involved in cross-links between lipid metabolism and the innate immune system. A better understanding of the genetic basis and molecular mechanisms of disease pathogenesis is an important step towards solving the problems of its early diagnosis and treatment.
动脉粥样硬化是现代社会最重要的医学和社会问题之一。动脉粥样硬化导致大量住院、残疾和死亡。相当多的证据表明，炎症是动脉粥样硬化发病机制中的关键环节之一。血管壁中的炎症与脂质代谢有广泛的交联，脂质介质作为调节血管壁炎症的中心环节发挥作用。遗传学和表观遗传因素在动脉粥样硬化发展中的作用的数据引起了极大的关注。越来越多的证据加强了对基因多态性以及涉及脂质代谢和固有免疫系统之间交联的基因表达失调的重要性的理解。更好地了解疾病发病机制的遗传基础和分子机制是解决其早期诊断和治疗问题的重要步骤。
