Fassbender Cordula, Klingel Reinhard, Köhler Wolfgang
Apheresis Research Institute, Cologne, Germany.
Apheresis Research Institute, Cologne, Germany.
Atheroscler Suppl. 2017 Nov;30:257-263. doi: 10.1016/j.atherosclerosissup.2017.05.041. Epub 2017 Jun 2.
Autoimmune encephalitis is a severe inflammatory disorder of the brain. The discovery that several non-infectious forms of encephalitis are associated with autoantibodies was a breakthrough in the care of this previously untreatable group of patients. The correlation of antibody type and titer with pattern and severity of symptoms was essential for the initiation of immunotherapies. First line therapy consists of steroids, intravenous immunoglobulins, plasma exchange or immunoadsorption. Rapid elimination of autoantibodies using selective immunoadsorption and avoiding the disadvantage of plasma substitution is a pathophysiologically guided therapeutic approach, and has been proven to be an effective therapeutic option as part of multimodal immunotherapy.
自身免疫性脑炎是一种严重的脑部炎症性疾病。几种非感染性脑炎形式与自身抗体相关这一发现，是这类此前无法治疗的患者护理方面的一项突破。抗体类型和滴度与症状模式及严重程度的相关性，对于启动免疫疗法至关重要。一线治疗包括使用类固醇、静脉注射免疫球蛋白、血浆置换或免疫吸附。采用选择性免疫吸附快速清除自身抗体并避免血浆置换的弊端，是一种基于病理生理学的治疗方法，并且已被证明是多模式免疫疗法的一种有效治疗选择。
