Caparó Oblitas Rubén L
Hospital Nacional Edgardo Rebagliati Martins, Lima, Perú. E-mail:
Medicina (B Aires). 2018;78 Suppl 2:88-93.
Autoimmune encephalitis is a new group of diseases of great clinical and therapeutic importance due to the good response in most cases to the immunomodulatory therapy indicated, with a large percentage of healing without significant neurological effects (cognitive, motor, seizures or involuntary movements). Since 2007, the presence of neuronal autoantibodies in the pathogenesis of this group of diseases has been demonstrated, with psychotic symptoms and involuntary movements as clinical markers of the disease. The present review emphasizes the crucial leap and change of paradigms arising after the discovery of these encephalitis associated with antibodies.
自身免疫性脑炎是一组具有重大临床和治疗意义的新疾病，因为在大多数情况下，针对所指出的免疫调节治疗反应良好，很大比例的患者能够痊愈且无明显神经功能影响（认知、运动、癫痫发作或不自主运动）。自2007年以来，已证实神经元自身抗体在这组疾病的发病机制中存在，精神病性症状和不自主运动是该疾病的临床标志。本综述强调了在发现这些抗体相关脑炎后出现的关键飞跃和范式转变。
