Northern Ireland centre for stratified medicine, school of biomedical sciences, Ulster university, CTRIC building, Altnagelvin hospital, Glenshane Road, BT47 6SB Londonderry, Northern Ireland.
Northern Ireland centre for stratified medicine, school of biomedical sciences, Ulster university, CTRIC building, Altnagelvin hospital, Glenshane Road, BT47 6SB Londonderry, Northern Ireland.
Arch Cardiovasc Dis. 2017 Dec;110(12):700-711. doi: 10.1016/j.acvd.2017.08.002. Epub 2017 Oct 31.
Tumour necrosis factor alpha converting enzyme (TACE/ADAM17) is a member of the A disintegrin and metalloproteinase (ADAM) family of ectodomain shedding proteinases. It regulates many inflammatory processes by cleaving several transmembrane proteins, including tumour necrosis factor alpha (TNFα) and its receptors tumour necrosis factor alpha receptor 1 and tumour necrosis factor alpha receptor 2. There is evidence that TACE is involved in several inflammatory diseases, such as ischaemia, heart failure, arthritis, atherosclerosis, diabetes and cancer as well as neurological and immune diseases. This review summarizes the latest discoveries regarding the mechanism of action and regulation of TACE. It also focuses on the role of TACE in atherosclerosis and coronary artery disease (CAD), highlighting clinical studies that have investigated its expression and protein activity. The multitude of substrates cleaved by TACE make this enzyme an attractive target for therapy and a candidate for biomarker research and development in CAD.
肿瘤坏死因子α转化酶（TACE/ADAM17）是解聚素和金属蛋白酶（ADAM）家族的外肽酶脱落蛋白水解酶成员。它通过切割几种跨膜蛋白来调节许多炎症过程，包括肿瘤坏死因子α（TNFα）及其受体肿瘤坏死因子α受体 1 和肿瘤坏死因子α受体 2。有证据表明，TACE 参与了几种炎症性疾病，如缺血、心力衰竭、关节炎、动脉粥样硬化、糖尿病和癌症以及神经和免疫性疾病。这篇综述总结了关于 TACE 的作用机制和调节的最新发现。它还重点介绍了 TACE 在动脉粥样硬化和冠心病（CAD）中的作用，强调了研究其表达和蛋白活性的临床研究。TACE 切割的多种底物使这种酶成为治疗的有吸引力的靶点，也是 CAD 中生物标志物研究和开发的候选者。
