Department of Pain Medicine, Peking University People's Hospital, Beijing, China.
Institute of Behavioral Psychology, Henan University, Kaifeng, Henan, China.
Sci Rep. 2017 Nov 2;7(1):14966. doi: 10.1038/s41598-017-14879-8.
The aim of this study was to investigate the temporal correlations of neuronal oscillations in patients with mild spastic diplegia (MSD). Resting-state electroencephalography (EEG) was recorded from 15 male adolescent and young adult patients with MSD and 15 healthy controls. We characterized the temporal correlations of neuronal oscillations, both on long temporal scale (i.e., >1 second) and short-to-intermediate temporal scale (i.e., <≈1 second) using detrended fluctuation analysis (DFA) and an analysis of the life- and waiting-time statistics of oscillation bursts respectively. The DFA exponents at alpha and beta bands, the life-time biomarker of alpha oscillation, and the life- and waiting-time biomarkers of beta oscillation were significantly attenuated in the patients compared with controls. Moreover, altered scalp distributions of some temporal correlation measures were found at alpha and beta bands in these patients. All these findings suggest that MSD is associated with highly volatile neuronal states of alpha and beta oscillations on short-to-intermediate and much longer time scales, which may be related to cognitive dysfunction in patients with MSD.
本研究旨在探讨轻度痉挛性双侧瘫（MSD）患者神经元振荡的时程相关性。对 15 名男性青少年和年轻成年 MSD 患者和 15 名健康对照者进行静息态脑电图（EEG）记录。我们使用去趋势波动分析（DFA）和振荡爆发的生命和等待时间统计分析分别对长时程（即>1 秒）和短至中时程（即<≈1 秒）的神经元振荡的时程相关性进行了特征描述。与对照组相比，MSD 患者的 alpha 和 beta 波段的 DFA 指数、alpha 振荡的生命时间生物标志物以及 beta 振荡的生命和等待时间生物标志物均显著降低。此外，在这些患者的 alpha 和 beta 波段发现了一些时程相关测量值的头皮分布改变。所有这些发现表明，MSD 与 alpha 和 beta 振荡的短至中时程和更长时间尺度上的高度不稳定神经元状态有关，这可能与 MSD 患者的认知功能障碍有关。
