The long-range temporal correlations of broadband EEG oscillations in poststroke depression subjects with basal ganglia infarction.

Recent studies have found long-range temporal correlations (LRTC) of neuronal oscillation under different physiological and pathological state. In this paper we aimed to explore the temporal correlations of broadband neuronal oscillation in poststroke depression. Resting state EEGs of 16 electrodes in 16 poststroke depression (PSD), 18 poststroke non-depression (PSND) and 18 healthy control (HC) subjects were analyzed by means of detrended fluctuation analysis (DFA), a quantitative measurement of LRTC. The results indicated that LRTC of broadband oscillation in PSD subjects was still preserved and had similar spatial distribution to non-depression subjects, but attenuated especially in left hemisphere and frontal and posterior temporal regions of right hemisphere. Moreover, a linear correlation between the severity of psychiatric symptoms and attenuation of LRTC was observed in stroke subjects. ROC curves indicated a high discriminating ability of scaling exponents in prefrontal regions distinguishing PSD from PSND, suggesting the feasibility for LRTC as assessment indicators to PSD.