Schlech W F, Lee S H, Cook J, Rozee K R, MacIntosh N
Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia.
JAMA. 1989 Jan 20;261(3):411-3.
Two newborns of mothers carrying hepatitis B and at high risk for human immunodeficiency virus (HIV) infection developed HIV-positive test results by enzyme-linked immunosorbent assay and Western blot tests after birth. Both had been administered hepatitis B immune globulin within 48 hours of birth. Serological tests detected HIV antibody as long as 17 days after birth. Both newborns had received lots of hepatitis B immune globulin containing antibody to HIV. While hepatitis B immune globulin cannot transmit HIV infection to recipients, physicians should be aware that administration of older lots of this preparation may result in transiently positive tests for HIV antibody in the recipients. Lots manufactured from screened plasma do not contain antibody to HIV.
两名母亲携带乙肝且有感染人类免疫缺陷病毒（HIV）高风险的新生儿，出生后通过酶联免疫吸附测定和蛋白质印迹试验检测出HIV呈阳性。两人均在出生后48小时内接种了乙肝免疫球蛋白。血清学检测在出生后长达17天仍能检测到HIV抗体。两名新生儿均接种了含有HIV抗体的大量乙肝免疫球蛋白。虽然乙肝免疫球蛋白不会将HIV感染传播给接受者，但医生应意识到，使用该制剂的旧批次产品可能会导致接受者的HIV抗体检测出现短暂阳性。由经过筛查的血浆制成的批次产品不含HIV抗体。
