18F-FDG PET/MRE 指标与克罗恩病患者炎症生物标志物的相关性：一项初步研究。
Correlation of 18F-FDG PET/MRE Metrics with Inflammatory Biomarkers in Patients with Crohn's Disease: A Pilot Study.
机构信息
Department of Nuclear Medicine, Assuta Medical Centers and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
IBD Center, Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel.
出版信息
Contrast Media Mol Imaging. 2017 Sep 19;2017:7167292. doi: 10.1155/2017/7167292. eCollection 2017.
BACKGROUND
To investigate the association between 18F-FDG (Fluorodeoxyglucose) PET (positron emission tomography)/MRE (magnetic resonance enterography) metrics with the inflammatory biomarkers fecal calprotectin and C-reactive protein (CRP) in patients with Crohn's disease (CD).
METHODS
This prospective pilot study was institutional review board (IRB) approved with informed consent obtained. Consecutive CD patients were referred to 18F-FDG PET/MRE. Patients in whom colonoscopy was performed and CRP and fecal calprotectin levels were measured were included. CRP and fecal calprotectin were regarded as positive for inflammation if they were greater than 0.5 mg/dl and 150 mcg/g, respectively. Correlation of quantitative variables was performed using the Pearson's correlation coefficient. Receiver operating characteristic (ROC) curves were drawn and the area under the curve (AUC) was calculated to evaluate the accuracy of PET and MRE metrics in determining the presence of inflammation evaluated by calprotectin and CRP levels.
RESULTS
Analysis of 21 patients (16 women and 5 men, 43 ± 18 years) was performed. Magnetic resonance index of activity (MaRIA) score had an AUC of 0.63 associated with fecal calprotectin and CRP. Adding apparent diffusion coefficient (ADC) and metabolic inflammatory volume (MIV) to MaRIA score resulted in an AUC of 0.92 with a cutoff value of 447 resulting in 83% and 100% sensitivity and specificity, respectively.
CONCLUSION
The addition of ADC and MIV to the MaRIA score increases the accuracy for discrimination of disease activity in patients with CD. is 2015062.
背景
研究目的在于探讨 18F-FDG（氟代脱氧葡萄糖）正电子发射断层扫描/磁共振肠造影术（MRE）各项指标与克罗恩病（CD）患者的炎症生物标志物粪便钙卫蛋白和 C 反应蛋白（CRP）之间的相关性。
方法
该前瞻性试点研究获得机构审查委员会（IRB）批准并获得知情同意。连续纳入进行 18F-FDG PET/MRE 检查的 CD 患者。纳入同时行结肠镜检查并测量 CRP 和粪便钙卫蛋白水平的患者。CRP 和粪便钙卫蛋白的炎症临界值分别为>0.5mg/dl 和 150mcg/g。采用 Pearson 相关系数分析定量变量的相关性。绘制受试者工作特征（ROC）曲线，计算曲线下面积（AUC）以评估 PET 和 MRE 指标在确定由 calprotectin 和 CRP 水平评估的炎症存在方面的准确性。
结果
共分析 21 例患者（16 名女性和 5 名男性，年龄 43±18 岁）。磁共振活动指数（MaRIA）评分与粪便钙卫蛋白和 CRP 均具有相关性，AUC 为 0.63。将表观扩散系数（ADC）和代谢性炎症体积（MIV）加入 MaRIA 评分后，AUC 为 0.92，截断值为 447，灵敏度和特异性分别为 83%和 100%。
结论
MaRIA 评分中加入 ADC 和 MIV 可提高区分 CD 患者疾病活动度的准确性。
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