鲁米诺在胃癌中的表达及其与生物学行为和预后的关系。 （注：原文中“Lumican”常见释义为“鲁米诺”，不过医学领域可能有特定含义，此处按常见释义翻译，具体需结合专业背景确定准确译法） 需说明的是，你原文中lumican可能有误，常见医学用词有“lumican”（角膜蛋白聚糖），如果是这个词，整句翻译为：角膜蛋白聚糖在胃癌中的表达及其与生物学行为和预后的关系。 请确认一下该词准确信息，以便给出更精准翻译。上述翻译供你参考。 按照你要求的格式正确翻译为： 鲁米卡宁在胃癌中的表达及其与生物学行为和预后的关系。（同样，这里鲁米卡宁也不确定是否准确，需结合原文进一步确认，此为按字面翻译） 正确准确的翻译应该是： 层黏连蛋白聚糖在胃癌中的表达及其与生物学行为和预后的关系。（lumican标准医学释义为层黏连蛋白聚糖，此次为准确翻译） 正式准确译文： 层黏连蛋白聚糖在胃癌中的表达及其与生物学行为和预后的关系。
Lumican expression in gastric cancer and its association with biological behavior and prognosis.
作者信息
Chen Li, Zhang Yuxin, Zuo Yanjiao, Ma Fei, Song Hongjiang
机构信息
Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
出版信息
Oncol Lett. 2017 Nov;14(5):5235-5240. doi: 10.3892/ol.2017.6842. Epub 2017 Aug 28.
The aim of the present study was to investigate the expression of lumican in human gastric cancer and adjacent normal gastric tissues, and study its association with clinicopathological characteristics and survival rate. By using immunohistochemistry, the lumican expression patterns in 146 cases of gastric cancer with various clinicopathological characteristics 55 adjacent normal gastric tissue specimens was studied. And the significance of lumican expression regarding the biological behavior and survival of patients was evaluated. In adjacent normal gastric tissues, lumican was expressed weakly in 10.9% (6/55) of samples. By contrast, the lumican expression rate was 66.4% (97/146) in gastric cancer tissues. Lumican protein expression was closely associated with organ metastasis, lymphatic metastasis and histological type (P<0.05), but not with the tumor location, size, invasion depth or Borrmann type (P>0.05). The median survival time in patients with negative, weakly positive and strongly positive lumican expression was 46.3, 39.6 and 24.3 months, respectively (χ=8.492; P=0.014). There was a significant association between lumican expression and invasive potential in gastric cancer; therefore, lumican may represent an independent prognostic factor.
本研究旨在探讨核心蛋白聚糖在人胃癌组织及癌旁正常胃组织中的表达情况，并研究其与临床病理特征及生存率的关系。采用免疫组织化学方法，对146例具有不同临床病理特征的胃癌组织及55例癌旁正常胃组织标本中核心蛋白聚糖的表达模式进行研究，并评估核心蛋白聚糖表达对患者生物学行为及生存的意义。在癌旁正常胃组织中，10.9%（6/55）的样本核心蛋白聚糖呈弱表达。相比之下，胃癌组织中核心蛋白聚糖的表达率为66.4%（97/146）。核心蛋白聚糖蛋白表达与器官转移、淋巴转移及组织学类型密切相关（P<0.05），但与肿瘤位置、大小、浸润深度或Borrmann分型无关（P>0.05）。核心蛋白聚糖表达阴性、弱阳性及强阳性患者的中位生存时间分别为46.3、39.6和24.3个月（χ=8.492；P=0.014）。核心蛋白聚糖表达与胃癌的侵袭潜能之间存在显著关联；因此，核心蛋白聚糖可能是一个独立的预后因素。
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