Wang Xiangcheng, He Yulin, Zhou Weina, Bai Xia, Wu Yiwei, Wang Xuemei, Li Xiao-Feng
Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China.
Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China.
Oncol Lett. 2017 Nov;14(5):5279-5284. doi: 10.3892/ol.2017.6840. Epub 2017 Aug 28.
In a mouse model of human lung cancer, intratumoral distribution between 3'-deoxy-3'-[F] fluorothymidine (F-FLT) and [F] fluorodeoxyglucose (F-FDG) was mutually exclusive. F-FLT primarily accumulated in proliferating cancer cells, whereas F-FDG accumulated in hypoxic cancer cells. The aim of the present study was to evaluate these preclinical findings in patients with lung cancer. A total of 55 patients with solitary pulmonary lesion were included in the present study. Patients underwent F-FLT positron emission tomography-computed tomography (PET/CT) and F-FDG PET/CT scan with a 3-day interval. The final diagnosis was based on histological examination. Among the 55 cases, a total of 24 cases were confirmed as malignant lesions. Mismatched F-FLT- and F-FDG-accumulated regions were observed in 19 cases (79%) and matched in 5 (21%). Among the 31 benign lesions, F-FLT and F-FDG were mismatched in 12 cases (39%) and matched in 19 (61%). The difference in intratumoral distribution of F-FLT and F-FDG between malignant and benign lesions was statistically significant (P<0.05). The results of the present study indicate that a mismatch in intratumoral distribution of F-FLT and F-FDG may be a feature of patients with lung cancer. Increased F-FDG accumulation may serve as an indicator of tumor hypoxia, whereas regions with increased F-FLT uptake may be associated with an increased rate of cancer cell proliferation in patients with lung cancer.
在人肺癌小鼠模型中，3'-脱氧-3'-[F]氟胸腺嘧啶核苷（F-FLT）和[F]氟脱氧葡萄糖（F-FDG）在肿瘤内的分布相互排斥。F-FLT主要积聚在增殖的癌细胞中，而F-FDG积聚在缺氧的癌细胞中。本研究的目的是评估肺癌患者的这些临床前研究结果。本研究共纳入55例孤立性肺病变患者。患者间隔3天分别接受F-FLT正电子发射断层扫描-计算机断层扫描（PET/CT）和F-FDG PET/CT扫描。最终诊断基于组织学检查。在这55例病例中，共有24例被确认为恶性病变。19例（79%）观察到F-FLT和F-FDG积聚区域不匹配，5例（21%）匹配。在31例良性病变中，F-FLT和F-FDG不匹配的有12例（39%），匹配的有19例（61%）。恶性和良性病变之间F-FLT和F-FDG在肿瘤内分布的差异具有统计学意义（P<0.05）。本研究结果表明，F-FLT和F-FDG在肿瘤内分布不匹配可能是肺癌患者的一个特征。F-FDG积聚增加可能作为肿瘤缺氧的指标，而F-FLT摄取增加的区域可能与肺癌患者癌细胞增殖率增加有关。
