Appleton D B, Isles A F, Tiernan J R
Clin Exp Neurol. 1978;15:271-8.
Aggressive chemotherapy and prophylactic central nervous system irradiation have increased the survival time of children with acute lymphatic leukaemia. As a result of treatment complex neurological problems are appearing. Computerized axial tomography allows more definite elucidation of these problems. 7 of 11 treated patients studied by this technique showed the presence of intracranial calcification and patchy cerebral atrophy, raising the questions of the quality of survival and the relationship of the findings to the cytotoxic drugs used.
积极的化疗和预防性中枢神经系统照射延长了急性淋巴细胞白血病患儿的生存时间。治疗的结果是出现了复杂的神经问题。计算机断层扫描能够更确切地阐明这些问题。在接受这项技术研究的11名接受治疗的患者中，有7名显示存在颅内钙化和局灶性脑萎缩，这引发了关于生存质量以及这些发现与所用细胞毒性药物之间关系的问题。
