Du Shuai-Gang, Guo Zhong-Hua, Kong Qian-Qian, Wang Xue-Chang, Zhou Song-Lin, Liu Yu-Ming
The Chinese Medicine Hospital of Henan, Zhengzhou 450009, China.
The Two Hospital Affiliated of Zhengzhou University, Zhengzhou 450002, China.
Zhongguo Zhong Yao Za Zhi. 2017 Jul;42(14):2802-2807. doi: 10.19540/j.cnki.cjcmm.20170523.004.
To explore the clinical effect of Sanbitang recipe in treatment for the rheumatoid arthritis (RA) with kidney empty and cold-dampness symptom and its safety. A total 168 cases eligible patients were randomly divided into the traditional Chinese medicine (TCM) group, the chemical medicine group and the TCM combined with chemical medicine group, with 56 cases in each group. The TCM group was treated with Sanbitang recipe; The chemical medicine group was given methotrexate tablets; And Sanbitang recipe and methotrexate tablets was adopted in the TCM combined with chemical medicine group. A course of treatment was 16 weeks. Health assessment questionnaire (HAQ), disease activity scores 28-joint counts (DAS28), visual analogue scale (VAS), TCM symptom, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), cyclic citrullinated peptides (CCP) and rheumatoid factor (RF) were detected. The efficiencies and incidence of adverse reactions in the three groups were compared. The total effective rate of the TCM combined with chemical medicine group was 92.7%, which was higher than 79.2% of the TCM group and 82.4% of the chemical medicine group (P<0.05). There was no statistically significant difference between the TCM group and the chemical medicine group. This suggested that Sanbitang recipe was effective in treating rheumatoid arthritis (RA) with kidney empty and cold-dampness symptom. After treatment, the scores of HAQ, DAS28, VAS, ESR, CRP, CCP and RF of the TCM combined with chemical medicine group were significantly higher (P<0.05) among the three groups. There was no statistically significant difference between the TCM group and the chemical medicine group. This indicated that Sanbitang recipe could effectively alleviate the clinical symptoms of rheumatoid arthritis (RA) with kidney empty and cold-dampness symptom. In terms of efficiency and incidence of adverse reactions, the order from low to high was that the TCM group (3.8%, 2/53)<the TCM combined with chemical medicine group (16.4%, 9/55)<the chemical medicine group (33.9%, 18/53) (P<0.05). Sanbitang recipe is effective in treating RA with kidney empty and cold-dampness symptom, with no obvious difference from methotrexate tablets and a low incidence of adverse reactions. Sanbitang recipe shows a remarkable effect in treating RA with kidney empty and cold-dampness symptom.
探讨三痹汤方治疗肾虚寒湿型类风湿关节炎（RA）的临床疗效及其安全性。将168例符合条件的患者随机分为中药组、化学药组和中药联合化学药组，每组56例。中药组采用三痹汤方治疗；化学药组给予甲氨蝶呤片；中药联合化学药组采用三痹汤方与甲氨蝶呤片联合治疗。疗程为16周。检测健康评估问卷（HAQ）、28个关节疾病活动评分（DAS28）、视觉模拟评分（VAS）、中医症状、红细胞沉降率（ESR）、C反应蛋白（CRP）、环瓜氨酸肽（CCP）和类风湿因子（RF）。比较三组的疗效及不良反应发生率。中药联合化学药组总有效率为92.7%，高于中药组的79.2%和化学药组的82.4%（P<0.05）。中药组与化学药组之间差异无统计学意义。这表明三痹汤方治疗肾虚寒湿型类风湿关节炎（RA）有效。治疗后，中药联合化学药组的HAQ、DAS28、VAS、ESR、CRP、CCP和RF评分在三组中显著更高（P<0.05）。中药组与化学药组之间差异无统计学意义。这表明三痹汤方可有效缓解肾虚寒湿型类风湿关节炎（RA）的临床症状。在疗效和不良反应发生率方面，由低到高的顺序为中药组（3.8%，2/53）<中药联合化学药组（16.4%，9/55）<化学药组（33.9%，18/53）（P<0.05）。三痹汤方治疗肾虚寒湿型RA有效，与甲氨蝶呤片疗效无明显差异，不良反应发生率低。三痹汤方治疗肾虚寒湿型RA疗效显著。
