Dobkin B H
Department of Neurology, University of California, Los Angeles.
Neurology. 1989 Jan;39(1):30-4. doi: 10.1212/wnl.39.1.30.
Thirteen patients presented with brief, repetitive, stereotyped transient ischemic attacks, large artery atherostenoses or occlusions with impaired collateral flow to a cortical perfusion borderzone, and orthostatic hypotension (OH). OH was caused by diabetes mellitus, aging, and treatments for ischemic heart disease and hypertension. Medical management of OH often eliminated the need for stroke prevention measures such as surgery or anticoagulation. Focal cerebral hypoperfusion from the combination of occlusive vascular disease and OH may be an underreported, treatable cause of TIA and stroke.
13例患者出现短暂、重复、刻板的短暂性脑缺血发作，大动脉粥样硬化狭窄或闭塞，伴有向皮质灌注边缘区的侧支血流受损，以及体位性低血压（OH）。OH由糖尿病、衰老以及缺血性心脏病和高血压的治疗引起。OH的药物治疗常常使手术或抗凝等预防中风措施不再必要。闭塞性血管疾病和OH共同导致的局灶性脑灌注不足可能是TIA和中风的一个未被充分报道但可治疗的病因。
