López-Bautista Fabiola, Posadas-Romero Carlos, Cardoso-Saldaña Guillermo, Juárez-Rojas Juan Gabriel, Medina-Urrutia Aida, Pérez-Hernández Nonanzit, Rodríguez-Pérez José Manuel, Vargas-Alarcón Gilberto, Posadas-Sánchez Rosalinda
Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México.
Gac Med Mex. 2017;153(5):566-574. doi: 10.24875/GMM.17002930.
To investigate the independent association between vitamin D deficiency (VDD) and coronary artery disease (CAD) in Mexican adult population.
Matched case-control study. Data cardiovascular on risk factors, medication use, physical activity, alcohol use, smoking and vitamin D consumption were obtained. Biochemical variables, anthropometric and blood pressure were measured. 25(OH)D was quantified by chemiluminescence.
We studied 250 patients with established CAD and 250 age-gender-body mass index (BMI) matched control subjects, with a mean age of 53 ± 6.1 years and BMI of 28 ± 3.5 kg/m. Deficiency of 25(OH)D was significantly higher in the control group (21.2 vs. 16%). Multiple logistic regression analysis did not show association between VDD and CAD (OR: 1.37 [0.08-23.2]). Multiple linear regression analysis also showed that statin use (b = 2.2; p = 0.004) and no alcohol use (b = -1.8; p = 0.03) significantly increased 25(OH)D levels.
No independent association between VDD and the presence of coronary artery disease was found in Mexican adult population. The results suggest that treatment with statins and absence of alcohol consumption, might be the explanation for the higher concentrations of 25(OH)D observed in patients with CAD.
研究墨西哥成年人群中维生素D缺乏（VDD）与冠状动脉疾病（CAD）之间的独立关联。
配对病例对照研究。获取心血管疾病危险因素、用药情况、身体活动、饮酒、吸烟及维生素D摄入的数据。测量生化指标、人体测量学指标及血压。采用化学发光法对25(OH)D进行定量分析。
我们研究了250例确诊CAD患者及250例年龄、性别、体重指数（BMI）匹配的对照者，平均年龄为53±6.1岁，BMI为28±3.5kg/m²。对照组中25(OH)D缺乏率显著更高（21.2%对16%）。多因素logistic回归分析未显示VDD与CAD之间存在关联（比值比：1.37[0.08 - 23.2]）。多因素线性回归分析还显示，使用他汀类药物（b = 2.2；p = 0.004）及不饮酒（b = -1.8；p = 0.03）可显著提高25(OH)D水平。
在墨西哥成年人群中未发现VDD与冠状动脉疾病存在独立关联。结果表明，他汀类药物治疗及不饮酒可能是CAD患者25(OH)D浓度较高的原因。
