Xu Rui, Li Yan-Yan, Ma Ling-Ling, Yang Hong-Ni
Gerontology center.
Department of cardiac surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Medicine (Baltimore). 2020 Mar;99(11):e19544. doi: 10.1097/MD.0000000000019544.
The relationship between coronary artery disease (CAD) and low serum 25-hydroxyvitamin D (25(OH)D) levels has emerged. Postmenopausal (PM) women are at increased risk of CAD and vitamin D (VitD) deficiency.To investigate the relationship between CAD and VitD levels in PM women.This case-control study included 93 consecutive female patients aged 50 to 79 years old undergoing coronary angiography for evaluation of CAD and 119 age-matched controls. Serum 25(OH)D concentrations were classed as adequate (serum 25(OH)D: ≥20 ng/mL); insufficient (serum 25(OH)D: 10 to <20 ng/mL); and deficient (serum 25(OH)D: <10 ng/mL). Major cardiovascular risk factors were also explored.CAD occurred in 67/127 (52.8%) patients with VitD deficiency; 21/66 (31.8%) patients that were VitD insufficient; and in 5/19 (26.3%) patients with adequate VitD levels. Multivariate regression analysis suggested that a deficiency of VitD increased CAD (odds ratio = 2.891; 95% confidence interval = 1.459-7.139, P < .001).VitD deficiency should be evaluated in PM women as a possible cause of CAD.
冠状动脉疾病（CAD）与低血清25-羟基维生素D（25(OH)D）水平之间的关系已显现出来。绝经后（PM）女性患CAD和维生素D（VitD）缺乏的风险增加。为了研究PM女性中CAD与VitD水平之间的关系。这项病例对照研究纳入了93例年龄在50至79岁之间连续接受冠状动脉造影以评估CAD的女性患者以及119例年龄匹配的对照。血清25(OH)D浓度被分类为充足（血清25(OH)D：≥20 ng/mL）；不足（血清25(OH)D：10至<20 ng/mL）；以及缺乏（血清25(OH)D：<10 ng/mL）。还探讨了主要心血管危险因素。CAD发生在67/127（52.8%）VitD缺乏的患者中；21/66（31.8%）VitD不足的患者中；以及5/19（26.3%）VitD水平充足的患者中。多变量回归分析表明，VitD缺乏会增加CAD的发生风险（优势比=2.891；95%置信区间=1.459 - 7.139，P<0.001）。在PM女性中应评估VitD缺乏作为CAD可能病因的情况。
