孤儿CpG岛作为替代启动子。
Orphan CpG islands as alternative promoters.
作者信息
Sarda Shrutii, Hannenhalli Sridhar
机构信息
a Center for Bioinformatics and Computational Biology , University of Maryland , College Park , MD , USA.
出版信息
Transcription. 2018;9(3):171-176. doi: 10.1080/21541264.2017.1373209. Epub 2017 Nov 28.
Abstract
CpG islands (CGIs) are associated with ∼60% of mammalian promoters. Most unmethylated CGIs exhibit transcriptional activity, which has led to their co-option as promoters by retrogenes. CGIs may also serve as alternative promoters for downstream genes with methylated promoters, with implications on aberrant activation of oncogenes in cancer phenotypes.
摘要
CpG岛（CGIs）与约60%的哺乳动物启动子相关。大多数未甲基化的CGIs表现出转录活性，这导致它们被反转录基因用作启动子。CGIs还可能作为甲基化启动子的下游基因的替代启动子，这对癌症表型中癌基因的异常激活具有影响。
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