Lytvynenko M, Bocharova T, Zhelezniakova N, Narbutova T, Gargin V
Odessa National Medical University, Odessa; Kharkiv National Medical University, Kharkiv, Ukraine.
Georgian Med News. 2017 Oct(271):12-17.
Patients with alcohol consumption have unclear risk of developing cervical cancer. The purpose of our work was detection of cervical neoplastic transformation in women with alcohol abuse. We investigated 13 cases of cervical neoplastic transformation (5 cases of invasive carcinoma and 8 case of cervical intraepithelial neoplasia (CIN)) which where detected occasionally during autopsy of alcohol abuse women. Microscopic investigation with immunohistochemistry (IHC) was performed indirect to Ki-67, p16. There are some peculiarities in development of cervical cancer in women with alcohol consumption. Level of cellular proliferation is significantly higher with positive staining Ki67 ranged from 29.1% to 89.7% in alcohol abuse group despite ranged from 27.41% to 75.3% in comparison group depend of transformation stage. Simultaneously, positive staining p16 was ranged from 26.2% to 94.8 % in alcohol abuse group despite ranged from 16.1% to 93.7% in comparison group. Diffuse staining with p16, specific gravity of cells with positive IHC reaction with this protein and high reaction intensity can be used as a specific and sensitive method for detecting CIN III and invasive carcinoma in alcohol abuse.
饮酒患者患宫颈癌的风险尚不明确。我们这项工作的目的是检测酗酒女性的宫颈肿瘤转化情况。我们调查了13例宫颈肿瘤转化病例（5例浸润癌和8例宫颈上皮内瘤变（CIN）），这些病例是在对酗酒女性进行尸检时偶然发现的。采用免疫组织化学（IHC）对Ki-67、p16进行间接显微镜检查。饮酒女性宫颈癌的发生存在一些特点。尽管对照组中Ki67阳性染色率根据转化阶段不同在27.41%至75.3%之间，但酗酒组细胞增殖水平明显更高，Ki67阳性染色率在29.1%至89.7%之间。同时，酗酒组p16阳性染色率在26.2%至94.8%之间，而对照组在16.1%至93.7%之间。p16的弥漫性染色、该蛋白免疫组化反应阳性细胞的比重以及高反应强度可作为检测酗酒女性CIN III和浸润癌的特异且敏感的方法。
