[STUDY OF THE PTPN22 GENE IN CHILDREN WITH TYPE 1 DIABETES MELLITUS IN THE AZERBAIJANI POPULATION].

The PTPN22 gene was studied in 160 children with type 1 diabetes mellitus under the age of 18 years and in 271 healthy children. Of the 160 patients, 50.6% (n=81) were boys, 49.4% (n=79) were girls. The average age of diabetic children was 9.1 years. The survey was conducted on the basis of the Children's Clinical Hospital No. 6 in Baku city. For all patients, a special questionnaire was filled out. Only children of Azerbaijani nationality were included in the study. As a comparison group, 271 students of the Medical College No. 1 of Baku city were involved. Of these, 29.1% (n=79) were boys, 70.9% (n = 192) girls. The control group did not include children with endocrine diseases. The collected blood samples were sent for further investigation to the medical genetic laboratory of the University Hospital of Motol at Charles University, located in the city of Prague (Czech Republic). This laboratory has a European certificate for conducting molecular genetic studies. In the Azerbaijani population, 3 polymorphisms of the PTPN22 gene were studied: 1123 (rs2488457), +1848 (rs2476601, or R620W), +2740 (rs1217412). Relationship with insulin-dependent diabetes mellitus was found only in polymorphism R620W. In this case, a minor allele (W) was found in 8 (5%) patients with diabetes mellitus and only 2 (0.74%) of healthy children, which is a reliable result (OR 7.1, 95% CI = 1.5 -34). Polymorphisms -1123 C/G and +2740 A/G showed no correlation with diabetes mellitus. The Azerbaijani population has higher odds ratios for haplotypes-1123C W620 + 2740G (OR 14.8, 95% CI=2.0-651). No inter-sex correlation was observed in the examined. At the same time, the trend was also not revealed.