Osipiani B, Machavariani T, Gvamichava T, Gachechiladze I, Nikobadze E
Iv. Javakhishvili Tbilisi State University, A.N. Natishvili Institute of Morphology, Tbilisi, Georgia.
Georgian Med News. 2017 Oct(271):102-106.
It is commonly known that in diabetes mellitus the risk of cardiovascular diseases and mortality increases. The purpose of this study was to determine the specific features of the morphological restructuring of the myocardium in the early stage of experimental diabetes and use the combined impact of powerful antioxidants (Vitamin C and Vitamin E) on the rat myocardium in conditions of alloxan-induced diabetes. The experimental animals were divided into three groups: 40 rats were the target, and 20 rats were the control. Target rats were divided into 2 groups: 1) group consisted of 20 rats with alloxan-induced diabetes; 2) group of 20 rats, which after confirmation of alloxan-induced diabetes, during 4 weeks were given intramuscularly vitamins C and E. The material was studied by histological and electron microscopic methods of investigation In the early stage of DM development, structural alterations in the cardiomyocytes and microcirculatory channels can be observed in the heart. Aggregation and agglutination of red blood cells and endothelial cell destruction were found in some vessels. In the study the result of combined therapy of Vitamin C and Vitamin E is a decrease in blood glucose levels, increases of endothelial proliferation, promoting the formation of new capillaries and further reduction of the structural changes of cardiomyocytes. Apperently through its antioxidative and anti-inflammatory activity Vitamins C and E stabilizes the metabolism processes in the vascular system and consequently, improvement of the organ function.
众所周知，在糖尿病中，心血管疾病的风险和死亡率会增加。本研究的目的是确定实验性糖尿病早期心肌形态重构的具体特征，并研究在四氧嘧啶诱导的糖尿病条件下，强效抗氧化剂（维生素C和维生素E）对大鼠心肌的联合影响。将实验动物分为三组：40只大鼠为目标组，20只大鼠为对照组。目标组大鼠分为2组：1）由20只四氧嘧啶诱导糖尿病的大鼠组成的组；2）20只大鼠组成的组，在确认四氧嘧啶诱导的糖尿病后，在4周内肌肉注射维生素C和维生素E。通过组织学和电子显微镜检查方法对材料进行研究。在糖尿病发展的早期阶段，心脏中可观察到心肌细胞和微循环通道的结构改变。在一些血管中发现红细胞聚集和凝集以及内皮细胞破坏。在该研究中，维生素C和维生素E联合治疗的结果是血糖水平降低、内皮细胞增殖增加、促进新毛细血管形成以及心肌细胞结构变化进一步减少。显然，维生素C和维生素E通过其抗氧化和抗炎活性稳定了血管系统中的代谢过程，从而改善了器官功能。
