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良性声带病变:命名、病因、诊断及治疗的最新进展

Benign vocal fold lesions: update on nomenclature, cause, diagnosis, and treatment.

作者信息

Naunheim Matthew R, Carroll Thomas L

机构信息

aDepartment of Otolaryngology, Massachusetts Eye and Ear InfirmarybDivision of Otolaryngology, Brigham and Women's HospitalcDepartment of Otolaryngology, Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Curr Opin Otolaryngol Head Neck Surg. 2017 Dec;25(6):453-458. doi: 10.1097/MOO.0000000000000408.

Abstract

PURPOSE OF REVIEW

The management of benign vocal fold lesions (BVFLs) continues to evolve. This article will review the recent literature surrounding the nomenclature, cause, diagnosis, and treatment of BVFLs, including polyps, nodules, cysts, and reactive lesions.

RECENT FINDINGS

The taxonomy of vocal fold lesions has been refined, and it serves as a common descriptive language for diagnosis, treatment algorithms, and reporting of outcomes. Though these lesions are known to be the result of phonotrauma, investigation into inflammatory mediators, apoptosis, and laryngopharyngeal reflux provide further elucidation of their underlying pathophysiology. The future of diagnosis, for which direct fiberoptic visualization and stroboscopy are the current gold standard, may utilize narrow-band imaging and videokymography; the clinical utility of ultrasound and optical coherence tomography is more remote. Angiolytic laser therapy and intralesional steroid injection are acceptable options for treatment of BVFLs. Voice therapy and microsurgical excision are mainstays of treatment.

SUMMARY

Recent clinical and basic science research has expanded upon an extensive literature surrounding the nomenclature, cause, diagnosis, and treatment of benign subepithelial vocal fold lesions. There remains a strong need for the advancement of rigorous diagnostic principles, evaluation of therapeutic interventions, and development of best practices guidelines.

摘要

综述目的

良性声带病变(BVFLs)的管理方法不断发展。本文将综述近期有关BVFLs(包括息肉、小结、囊肿和反应性病变)的命名、病因、诊断及治疗的文献。

最新发现

声带病变的分类已得到完善,它为诊断、治疗方案及疗效报告提供了通用的描述性语言。尽管已知这些病变是发声创伤的结果,但对炎症介质、细胞凋亡及喉咽反流的研究进一步阐明了其潜在的病理生理学机制。目前诊断的金标准是直接纤维喉镜检查和频闪喉镜检查,未来可能会采用窄带成像和视频记波法;超声和光学相干断层扫描的临床应用则更为遥远。血管溶解激光治疗和病灶内注射类固醇是治疗BVFLs的可接受选择。嗓音治疗和显微手术切除是主要的治疗方法。

总结

近期的临床和基础科学研究在围绕良性上皮下声带病变的命名、病因、诊断及治疗的大量文献基础上进行了拓展。仍迫切需要推进严格的诊断原则、评估治疗干预措施并制定最佳实践指南。

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