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中国 20 个省份肉类和肉类产品中短链和中链氯化石蜡的膳食暴露情况。

Dietary exposure to short- and medium-chain chlorinated paraffins in meat and meat products from 20 provinces of China.

机构信息

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China; University of Chinese Academy of Sciences, Beijing 100085, China.

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100085, China.

出版信息

Environ Pollut. 2018 Feb;233:439-445. doi: 10.1016/j.envpol.2017.10.022. Epub 2017 Nov 5.

Abstract

Food intake is one of the main pathways of human exposure to chlorinated paraffins (CPs). This study assessed the dietary exposure for the general Chinese population to short-chain chlorinated paraffin (SCCPs) and medium-chain chlorinated paraffins (MCCPs) through meat and meat products. Twenty samples of meat and meat products from 20 Chinese provinces were collected in 2011. As the sampling sites covered about two-thirds of the Chinese population, the meat samples were considered to be representative of the true characteristics of CPs contamination in Chinese meat products. The concentrations of SCCPs and MCCPs in the meat samples were measured using the comprehensive two-dimensional gas chromatography electron capture negative ionization high-resolution time-of-flight mass spectrometry method. Forty-eight SCCP and MCCP homolog groups were detected in the meat samples. The mean SCCP and MCCP concentrations in all meat samples were 129 ± 4.1 ng g wet weight and 5.7 ± 0.59 ng g wet weight, respectively. The concentrations of SCCPs and MCCPs varied in samples from different provinces. The geographical distribution of CP concentrations was similar to the distribution of CPs manufacturing plants in China. The most abundant groups of SCCPs in all samples were C Cl, and the most abundant groups of MCCPs in most samples were C Cl. The possible sources of SCCPs and MCCPs in meat and meat products might be CP-42 and CP-52. The 50th percentile estimated daily intakes of SCCPs and MCCPs through meat consumption for a "standard" Chinese adult male were 0.13 and 0.0047 μg kg bw d, respectively, both much lower than the tolerable daily intakes (TDIs) for SCCPs and MCCPs. This preliminary risk assessment has indicated that the indirect exposure of SCCPs and MCCPs through meat consumption does not pose significant risk to human health in China.

摘要

食物摄入是人类接触氯化石蜡(CPs)的主要途径之一。本研究通过肉类和肉类产品评估了中国一般人群对短链氯化石蜡(SCCPs)和中链氯化石蜡(MCCPs)的饮食暴露情况。2011 年,从中国 20 个省份采集了 20 个肉类和肉类产品样本。由于采样点覆盖了中国人口的三分之二左右,因此这些肉类样本被认为能够代表中国肉类产品中 CPs 污染的真实特征。使用全面二维气相色谱电子捕获负电离高分辨率飞行时间质谱法测量了肉类样品中 SCCPs 和 MCCPs 的浓度。在肉类样品中检测到 48 种 SCCP 和 MCCP 同系物组。所有肉类样品中 SCCP 和 MCCP 的平均浓度分别为 129 ± 4.1 ng g 湿重和 5.7 ± 0.59 ng g 湿重。不同省份的肉类样品中 SCCP 和 MCCP 的浓度存在差异。CP 浓度的地理分布与中国 CPs 制造工厂的分布相似。所有样品中最丰富的 SCCP 同系物组为 C Cl ,大多数样品中最丰富的 MCCP 同系物组为 C Cl 。肉类和肉类产品中 SCCPs 和 MCCPs 的可能来源可能是 CP-42 和 CP-52。通过食用肉类,“标准”中国成年男性对 SCCPs 和 MCCPs 的 50 百分位估计日摄入量分别为 0.13 和 0.0047 μg kg bw d,均远低于 SCCPs 和 MCCPs 的可耐受日摄入量(TDIs)。这项初步风险评估表明,通过食用肉类间接暴露于 SCCPs 和 MCCPs 不会对中国人群的健康造成显著风险。

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