Pourseif Mohammad Mostafa, Moghaddam Gholamali, Saeedi Nazli, Barzegari Abolfazl, Dehghani Jaber, Omidi Yadollah
Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Animal Sciences, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
Department of Animal Sciences, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
Biologicals. 2018 Jan;51:1-11. doi: 10.1016/j.biologicals.2017.10.003.
Cystic echinococcosis (CE) is one of the most important zoonotic parasite diseases in human, livestock, and wildlife worldwide. Development of effective vaccines against CE appears to be the most promising strategy to control this infectious disease. Use of potential livestock and canine vaccines against the larval and adult stage of E. granulosus life cycle may be the key to the production of powerful vaccines. Some progress has been accomplished in the development of vaccines against hydatidosis using empirical approaches, while such immunotherapies often fail to induce adequate immune responses. Therefore, it is of great interest to identify antigens (Ags) with high immunogenicity and develop effective vaccines and adjuvant constructs against CE. To this end, various tools can be applied, including immune-based genomics and proteomics, immunoinformatics, systems vaccinology and mathematical/computational modeling. In this review, we aimed to provide comprehensive insights upon the current status of vaccination trials against E. granulosus, and also articulate some perspectives on the production of novel anti-CE vaccines. Use of novel prospective technologies is also discussed to highlight the importance of development and advancement of the next generation vaccines against E. granulosus.
囊型包虫病（CE）是全球人类、家畜和野生动物中最重要的人畜共患寄生虫病之一。开发有效的抗CE疫苗似乎是控制这种传染病最有前景的策略。使用针对细粒棘球绦虫生命周期幼虫和成虫阶段的潜在家畜和犬用疫苗可能是生产强效疫苗的关键。使用经验性方法开发抗包虫病疫苗已取得一些进展，但此类免疫疗法往往无法诱导足够的免疫反应。因此，识别具有高免疫原性的抗原（Ags）并开发有效的抗CE疫苗和佐剂构建体具有重要意义。为此，可以应用各种工具，包括基于免疫的基因组学和蛋白质组学、免疫信息学、系统疫苗学以及数学/计算建模。在本综述中，我们旨在全面深入了解抗细粒棘球绦虫疫苗试验的现状，并就新型抗CE疫苗的生产阐明一些观点。还讨论了新型前瞻性技术的应用，以突出开发和推进下一代抗细粒棘球绦虫疫苗的重要性。
