Department of Neurosurgery, City of Hope, Duarte, CA.
Department of Neurosurgery, University of California, San Diego, San Diego, CA.
Clin Breast Cancer. 2018 Aug;18(4):e455-e467. doi: 10.1016/j.clbc.2017.10.002. Epub 2017 Oct 7.
Patients with breast cancer are surviving longer as the state of the art for care advances. Because patients are surviving longer with primary breast cancer, the incidence of secondary metastatic disease has risen. Metastatic breast cancer to the brain was once thought to be universally fatal. While it is still quite lethal, its treatment after diagnosis is increasingly safe and effective. Critical progress has been made in understanding the interaction between breast metastases and the neural niche, neuroimaging of functional anatomy, minimally invasive image-guided brain surgery, characterizing subtypes of breast cancer based on molecular and genetic profiles, and individualized pharmaceuticals and immunotherapies. In this review, we discuss recent advances that have brought us to state-of-the-art management of metastatic breast cancer to the brain.
随着治疗技术的进步，乳腺癌患者的生存时间越来越长。由于原发性乳腺癌患者的生存时间延长，继发性转移性疾病的发病率上升。转移性乳腺癌脑转移曾经被认为是普遍致命的。虽然它仍然非常致命，但在诊断后的治疗越来越安全有效。在理解乳腺癌转移与神经生态位之间的相互作用、功能解剖的神经影像学、微创图像引导脑外科手术、基于分子和遗传特征对乳腺癌亚型进行分类以及个体化药物和免疫疗法方面取得了重大进展。在这篇综述中，我们讨论了使我们能够对转移性乳腺癌脑转移进行最先进管理的最新进展。
