Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065, United States.
Department of Biology, Boston University, Boston, MA 02215, United States.
Mol Cell Endocrinol. 2018 May 15;467:21-30. doi: 10.1016/j.mce.2017.10.018. Epub 2017 Oct 31.
Testosterone (T) can act directly through neural androgen receptors (AR) to facilitate male sexual behavior; however, T's metabolites also can play complicated and interesting roles in the control of mating. One metabolite, dihydrotestosterone (DHT) binds to AR with significantly greater affinity than that of T. Is that important behaviorally? Another metabolite, estradiol (E), offers a potential alternative route of facilitating male mating behavior by acting through estradiol receptors (ER). In this review we explore the roles and relative importance of T as well as E and DHT at various levels of the neuroaxis for the activation of male sex behavior in common laboratory animals and, when relevant research findings are available, in man.
睾酮（T）可以通过神经雄激素受体（AR）直接作用，促进男性性行为；然而，T 的代谢物也可以在交配控制中发挥复杂而有趣的作用。一种代谢物，二氢睾酮（DHT）与 AR 的结合亲和力明显大于 T。这在行为上很重要吗？另一种代谢物，雌二醇（E），通过雌激素受体（ER）作用，提供了促进雄性交配行为的潜在替代途径。在这篇综述中，我们探讨了 T 以及 E 和 DHT 在常见实验室动物的神经轴的各个水平上对雄性性行为激活的作用和相对重要性，以及在相关研究结果可用的情况下，在人类中的作用。
