Watcho Pierre, Lih Fred, Brice Defo Deeh Patrick, Wankeu-Nya Modeste, Ngadjui Esther, Romeo Fozing Bonsou Georges, Kamanyi Albert, Kamtchouing Pierre
Department of Animal Biology, Faculty of Science, Animal Physiology and Phytopharmacology Laboratory, University of Dschang, Dschang, Cameroon.
Laboratory of Animal Biology and Physiology, Department of Animal Organisms Biology, University of Douala Douala, Cameroon.
Int J Reprod Biomed. 2019 Jul 29;17(6):413-424. doi: 10.18502/ijrm.v17i6.4813. eCollection 2019 Jun.
BACKGROUND: (Arecaceae) is a medicinal plant commonly used as a sexual enhancer. OBJECTIVE: To investigate the aphrodisiac potential of aqueous extract (AE) and methanolic extract (ME) of in sexually experienced male rats. MATERIALS AND METHODS: Thirty male Wistar rats were randomly distributed into six groups (5 rats per group) and administered for 14 days with distilled water (10 ml/kg), sildenafil citrate (1.44 mg/kg), and AE or ME of (100 or 500 mg/kg). The copulatory activity was tested on days 0, 7, and 14 using receptive females. Further, on day 14, rats were sacrificed and biochemical analyses (testosterone, total protein, and acid phosphatase) were performed. RESULTS: Sildenafil citrate significantly decreased the intromission latency (day 14, p = 0.04) and frequency (days 7 and 14, p = 0.03) but increased the mount frequency (day 14, p = 0.04), compared with control. Remarkably, enhanced the sexual activity by significantly decreasing the intromission latency (AE and ME, 500 mg/kg, day 14, p = 0.04) and increasing the mount frequency (AE and ME, 100 mg/kg, day 7, p = 0.02) compared with control. Moreover, improved plasmatic (AE, 100 mg/kg, p = 0.03; AE, 500 mg/kg, p = 0.001; ME, 100 mg/kg, p = 0.01) and testicular (AE, 100 mg/kg, p = 0.001; AE, 500 mg/kg, p = 0.01; ME, 100 mg/kg, p = 0.001; ME, 500 mg/kg, p = 0.01) testosterone levels as well as plasmatic total proteins concentration (ME, 500 mg/kg, p = 0.04). CONCLUSION: These findings showed that possesses an aphrodisiac property which could further justify its folkloric use in traditional medicine as a sexual enhancer.
背景：（棕榈科）是一种常用作性增强剂的药用植物。 目的：研究该植物水提取物（AE）和甲醇提取物（ME）对有性经验的雄性大鼠的壮阳潜力。 材料与方法：将30只雄性Wistar大鼠随机分为6组（每组5只），分别给予蒸馏水（10 ml/kg）、枸橼酸西地那非（1.44 mg/kg）以及该植物的AE或ME（100或500 mg/kg），持续给药14天。在第0、7和14天，使用处于发情期的雌性大鼠测试交配活动。此外，在第14天处死大鼠并进行生化分析（睾酮、总蛋白和酸性磷酸酶）。 结果：与对照组相比，枸橼酸西地那非显著缩短了插入潜伏期（第14天，p = 0.04）并降低了插入频率（第7和14天，p = 0.03），但增加了爬跨频率（第14天，p = 0.04）。值得注意的是，与对照组相比，该植物通过显著缩短插入潜伏期（AE和ME，500 mg/kg，第14天，p = 0.04）和增加爬跨频率（AE和ME，100 mg/kg，第7天，p = 0.02）增强了性活动。此外，该植物提高了血浆（AE，100 mg/kg，p = 0.03；AE，500 mg/kg，p = 0.001；ME，100 mg/kg，p = 0.01）和睾丸（AE，100 mg/kg，p = 0.001；AE，500 mg/kg，p = 0.01；ME，100 mg/kg，p = 0.001；ME，500 mg/kg，p = 0.01）中的睾酮水平以及血浆总蛋白浓度（ME，500 mg/kg，p = 0.04）。 结论：这些发现表明该植物具有壮阳特性，这可以进一步证明其在传统医学中作为性增强剂的民间用途是合理的。
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