Maisel A S, Scott N A, Motulsky H J, Michel M C, Boublik J H, Rivier J E, Ziegler M, Allen R S, Brown M R
Department of Medicine, University of California, San Diego.
Am J Med. 1989 Jan;86(1):43-8. doi: 10.1016/0002-9343(89)90228-3.
Our objectives were to assess whether plasma neuropeptide Y (NPY) levels are elevated in patients with congestive heart failure (CHF) and whether or not NPY levels can serve as a reliable indicator of sympathetic activity in CHF.
Plasma levels of the sympathetic neurotransmitters norepinephrine and epinephrine and of the sympathetic co-transmitter NPY were measured in 17 patients with CHF and 14 healthy control subjects at rest and after maximal exercise.
Under resting conditions, plasma NPY and norepinephrine levels were elevated in patients with CHF compared with control subjects (551 +/- 48 pg/ml versus 311 +/- 22 pg/ml, p less than or equal to 0.001 for NPY, and 306 +/- 73 pg/ml versus 124 +/- 22 pg/ml, p less than or equal to 0.02 for norepinephrine). Plasma NPY correlated better with plasma norepinephrine than with epinephrine, indicating its origin from sympathetic nerve terminals. Acute stimulation of sympathetic activity by dynamic exercise increased plasma norepinephrine levels in control subjects and patients with CHF, but did not significantly alter the mean plasma NPY value in the latter group.
NPY may play a role in the pathophysiology of CHF.
我们的目标是评估充血性心力衰竭（CHF）患者血浆神经肽Y（NPY）水平是否升高，以及NPY水平能否作为CHF交感神经活动的可靠指标。
在静息状态和最大运动后，测量了17例CHF患者和14名健康对照者血浆中交感神经递质去甲肾上腺素和肾上腺素以及交感神经共同递质NPY的水平。
在静息状态下，CHF患者血浆NPY和去甲肾上腺素水平高于对照者（NPY：551±48 pg/ml对311±22 pg/ml，p≤0.001；去甲肾上腺素：306±73 pg/ml对124±22 pg/ml，p≤0.02）。血浆NPY与血浆去甲肾上腺素的相关性优于与肾上腺素的相关性，表明其来源于交感神经末梢。动态运动对交感神经活动的急性刺激使对照者和CHF患者血浆去甲肾上腺素水平升高，但未显著改变CHF患者组的平均血浆NPY值。
NPY可能在CHF的病理生理学中起作用。
