Liu J J, Shi S G, Han Q D
Cardiology Department, Third Hospital, Beijing Medical University.
Zhonghua Nei Ke Za Zhi. 1994 Oct;33(10):687-9.
Plasma neuropeptide Y (NPY) was measured by radioimmunoassay in 43 patients with congestive heart failure (CHF) and 20 healthy control subjects. The results showed that plasma NPY levels were elevated in patients with CHF compared with control subjects (366 +/- 28 ng/L VS. 89 +/- 22 ng/L, P < 0.001). There was a close relationship between the severity of CHF and plasma NPY levels. The severer the CHF, the higher the NPY level. In addition, 20 of the 43 patients with symptoms improved after treatment for heart failure were followed. The results indicated a significant decrease of plasma NPY levels (333 +/- 42 ng/L VS. 157 +/- 25 ng/L, P < 0.01) in these patients. Furthermore, multiple logistic regression analysis demonstrated that the presence and severity of CHF were related to plasma NPY levels significantly and independently. Because of its potent vasoconstrictive and negative cardiac inotropic effects, NPY might be involved in the pathophysiology of CHF. Plasma NPY levels might be taken as a prognostic indicator in patients with CHF, but further investigation is needed.
采用放射免疫分析法测定了43例充血性心力衰竭（CHF）患者和20名健康对照者血浆神经肽Y（NPY）水平。结果显示，与对照组相比，CHF患者血浆NPY水平升高（366±28 ng/L对89±22 ng/L，P<0.001）。CHF严重程度与血浆NPY水平密切相关。CHF越严重，NPY水平越高。此外，对43例心力衰竭治疗后症状改善的患者中的20例进行了随访。结果表明，这些患者血浆NPY水平显著降低（333±42 ng/L对157±25 ng/L，P<0.01）。此外，多因素logistic回归分析表明，CHF的存在和严重程度与血浆NPY水平显著且独立相关。由于NPY具有强大的血管收缩和负性心肌收缩作用，它可能参与了CHF的病理生理过程。血浆NPY水平可能作为CHF患者的预后指标，但仍需进一步研究。
