Department of System Biology, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain; REDinREN (Instituto de Salud Carlos III), Madrid, Spain.
REDinREN (Instituto de Salud Carlos III), Madrid, Spain; Research Unit, Fundación para la Investigación Biomédica del Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
Exp Gerontol. 2017 Dec 15;100:87-90. doi: 10.1016/j.exger.2017.10.026. Epub 2017 Oct 31.
Integrin-linked kinase (ILK) is a protein located in focal adhesion complexes that is linked to the cytoplasmic domain of integrin receptors. Together with PINCH and parvin, ILK forms the IPP complex, which is associated with conserved intracellular signalling pathways and integrin regulation of the actin cytoskeleton. ILK plays an essential role in a wide variety of cellular functions, including cell migration, differentiation, survival, and division. The present review summarizes recent evidence, suggesting a new role for ILK in organismal ageing and cellular senescence, indicating that ILK is a key regulator of longevity and premature cellular senescence induced by extracellular stressors.
整合素连接激酶（ILK）是一种位于黏着斑复合物中的蛋白质，与整合素受体的胞质域相连。ILK 与 PINCH 和 parvin 一起形成 IPP 复合物，与保守的细胞内信号通路和整合素对肌动蛋白细胞骨架的调节有关。ILK 在广泛的细胞功能中发挥着重要作用，包括细胞迁移、分化、存活和分裂。本综述总结了最近的证据，表明 ILK 在机体衰老和细胞衰老中的新作用，表明 ILK 是由细胞外应激诱导的长寿和过早细胞衰老的关键调节剂。
