Bastidas J A, Yeo C J, Schmieg R E, Zinner M J
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Am J Surg. 1989 Jan;157(1):27-32. doi: 10.1016/0002-9610(89)90415-7.
The purpose of this study was to investigate the role of endogenous opiates in mediating meal-stimulated jejunal absorption. Jejunal Thiry-Vella loops, 25 cm long, were studied in awake conditioned dogs, using luminal perfusion with carbon-14 polyethylene glycol. Fluxes of water, sodium, and chloride were calculated every 15 minutes over a 1-hour basal period, followed by a 3-hour experimental period. The animals were divided into four groups: control, naloxone, meal, and meal plus naloxone. In the control and naloxone groups, the fluxes did not change over the 4-hour observation period. Meal alone immediately stimulated the absorption of water and electrolytes in the Thiry-Vella loop (p less than 0.05). The addition of naloxone infusion to the meal stimulus resulted in significantly reduced absorption during the first hour after the meal (p less than 0.05). We concluded that endogenous opiates play a role in meal-stimulated jejunal absorption.
本研究的目的是探讨内源性阿片类物质在介导进食刺激的空肠吸收中的作用。在清醒的条件反射犬中，使用含碳-14聚乙二醇的肠腔灌注法，研究了25厘米长的空肠Thiry-Vella肠袢。在1小时的基础期内，每15分钟计算一次水、钠和氯的通量，随后是3小时的实验期。动物被分为四组：对照组、纳洛酮组、进食组和进食加纳洛酮组。在对照组和纳洛酮组中，通量在4小时的观察期内没有变化。单独进食立即刺激了Thiry-Vella肠袢中水和电解质的吸收（p<0.05）。在进食刺激的基础上加入纳洛酮输注，导致进食后第一小时的吸收显著减少（p<0.。我们得出结论，内源性阿片类物质在进食刺激的空肠吸收中起作用。 0 )5
