Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, 143005, Punjab, India.
Department of Botany, Eternal University, Baru Sahib, Sirmour, 173101, Himachal Pradesh, India.
Biomed Pharmacother. 2018 Jan;97:564-586. doi: 10.1016/j.biopha.2017.10.124. Epub 2017 Nov 6.
Cancer is a leading cause of disease burden throughout the world. Many cancers develop as a result of exposure to both lifestyle and environmental factors that are potentially modifiable. In the last few years, much of the scientific attention has drawn to the discovery of new and effective chemopreventive agents from natural sources. A multitude of phytoconstituents have been explored for their potential to prevent the occurrence of carcinogenesis both in vitro and in vivo by means of diverse cellular and molecular approaches. Key focus of this review is to highlight some significant and new information about different molecular aspects of chemopreventive ability of plant based phytochemicals in terms of their inhibitory potential on cancer growth. In addition, information regarding certain limiting factors such as whole animal physiology, tumour microenvironment and bioavailability of active components of phytoconstituents used in pre/clinical trials are further explored. This review would further assist the scientific community involved in designing efficacious chemopreventive approaches using these phytochemicals in treating cancer.
癌症是全球疾病负担的主要原因。许多癌症是由于接触潜在可改变的生活方式和环境因素而发展的。在过去的几年中，大量的科学注意力集中在发现来自天然来源的新的和有效的化学预防剂上。已经探索了多种植物成分，以研究它们通过不同的细胞和分子方法在体外和体内预防致癌发生的潜力。本文的重点是强调一些关于植物源性植物化学物质化学预防能力的不同分子方面的重要和新信息，这些化学预防能力是基于它们对癌症生长的抑制潜力。此外，还进一步探讨了关于某些限制因素的信息，例如整体动物生理学、肿瘤微环境以及在临床前试验中使用的植物成分的有效成分的生物利用度。这篇综述将进一步帮助参与使用这些植物化学物质设计有效化学预防方法来治疗癌症的科学界。
