Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Curr Cancer Drug Targets. 2018;18(7):640-651. doi: 10.2174/1568009617666170623124710.
A growing body of evidence suggests that phytochemicals are potentially able to affect a variety of cellular processes, including proliferation, apoptosis, cell-cycle control, angiogenesis, inflammation, and DNA repair. Phytochemicals may typically play pleiotropic regulatory roles in cancer cells. Chemoprevention, which can be achieved by using these natural agents, has emerged as a helpful strategy to manage a variety of malignancies. With regard to cancer-associated chemopreventive mechanisms, phytochemicals can act by modulating microRNAs (miRNAs) and their target genes. This review aims to present an overview of recent findings on the effects of some wellcharacterized bioactive phytochemicals on miRNA regulation in different cancer types. The potential use of these phytochemicals for the chemoprevention and treatment of cancer is also discussed.
越来越多的证据表明，植物化学物质有可能影响多种细胞过程，包括增殖、凋亡、细胞周期控制、血管生成、炎症和 DNA 修复。植物化学物质通常可能在癌细胞中发挥多效性调节作用。通过使用这些天然剂来实现化学预防，已成为管理各种恶性肿瘤的一种有益策略。关于与癌症相关的化学预防机制，植物化学物质可以通过调节 microRNAs（miRNAs）及其靶基因来发挥作用。本综述旨在介绍一些具有良好特征的生物活性植物化学物质对不同癌症类型中 miRNA 调节作用的最新发现。还讨论了这些植物化学物质在癌症的化学预防和治疗中的潜在用途。
