Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, People's Republic of China.
School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People's Republic of China.
Biomed Pharmacother. 2018 Jan;97:642-651. doi: 10.1016/j.biopha.2017.10.067. Epub 2017 Nov 6.
Therapeutics for osteoarthritis (OA) are intended to restore chondrocyte function and inhibit cell apoptosis. Previous studies have shown that gastrodin had anti-apoptotic and anti- inflammatory effects. However, little is known about whether gastrodin has protective effects against the processes of OA. We studied the potential effects of gastrodin on chondrocytes and the underlying mechanisms. Our results showed that gastrodin could prevent chondrocyte apoptosis induced by IL-1β. Additionally, gastrodin suppressed the nuclear factor kappa B (NF-κB) pathway, decreased the release of inflammatory mediators (IL-6, TNF-α), and reduced matrix catabolism in IL-1β-treated chondrocytes. Furthermore, gastrodin ameliorated rat cartilage degeneration in an OA model of knee joints in vivo, suggesting its potential as a candidate therapeutic for OA.
骨关节炎（OA）的治疗方法旨在恢复软骨细胞功能并抑制细胞凋亡。先前的研究表明，天麻素具有抗凋亡和抗炎作用。然而，对于天麻素是否对 OA 过程具有保护作用知之甚少。我们研究了天麻素对软骨细胞的潜在影响及其潜在机制。结果表明，天麻素可预防 IL-1β诱导的软骨细胞凋亡。此外，天麻素抑制核因子 kappa B（NF-κB）通路，减少 IL-1β处理的软骨细胞中炎症介质（IL-6、TNF-α）的释放，并降低基质代谢。此外，天麻素在体内膝关节 OA 模型中改善了大鼠软骨退变，表明其可能成为 OA 的候选治疗药物。
