Xiao Guirong, Tang Rong, Yang Nan, Chen Yanhua
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Pharmacy, Sichuan Hospital of Stomatology, Chengdu, 610031, China.
Arch Pharm Res. 2023 Oct;46(9-10):744-770. doi: 10.1007/s12272-023-01463-0. Epub 2023 Sep 25.
Gastrodia elata Blume is a well-known traditional Chinese medicine that is mainly used to treat diseases related to the nervous system, such as stroke, epilepsy, and headache. Gastrodin is the main bioactive component of Gastrodia elata Blume, and studies have shown that it has extensive pharmacological activity. This narrative review aims to systematically review relevant studies on the pharmacological effects of gastrodin to provide researchers with the latest and most useful information. Studies have shown that gastrodin has prominent neuroprotective effects and can treat or improve epilepsy, Tourette syndrome, Alzheimer's disease, Parkinson's disease, emotional disorders, cerebral ischemia-reperfusion injury, cognitive impairment, and neuropathic pain. Gastrodin can also improve myocardial hypertrophy, hypertension, and myocardial ischemia-reperfusion injury. In addition, gastrodin can mitigate liver, kidney, and bone tissue damage caused by oxidative stress and inflammation. In short, gastrodin is expected to treat many diseases, and it is worth investing more effort in research on this compound.
天麻是一种著名的传统中药，主要用于治疗与神经系统相关的疾病，如中风、癫痫和头痛。天麻素是天麻的主要生物活性成分，研究表明它具有广泛的药理活性。本叙述性综述旨在系统回顾天麻素药理作用的相关研究，为研究人员提供最新和最有用的信息。研究表明，天麻素具有显著的神经保护作用，可治疗或改善癫痫、抽动秽语综合征、阿尔茨海默病、帕金森病、情绪障碍、脑缺血再灌注损伤、认知障碍和神经性疼痛。天麻素还可改善心肌肥大、高血压和心肌缺血再灌注损伤。此外，天麻素可减轻氧化应激和炎症引起的肝、肾和骨组织损伤。总之，天麻素有望治疗多种疾病，值得对该化合物投入更多的研究精力。
