Department of Pharmacology, College of Pharmacy, Aljouf University, Sakaka, KSA.
Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India.
Biomed Pharmacother. 2018 Jan;97:652-655. doi: 10.1016/j.biopha.2017.10.085. Epub 2017 Nov 6.
Evaluation of diphenhydramine in talc induced type 2 diabetes mellitus was done in Wistar rats. Oral administration of Talc (10mg/kg)carried out for 21days increased the levels of serum glutamate pyruvate transaminase (SGPT), glutamate oxaloacetate transaminase (SGOT), serum creatinine, blood glucose, urea, uric acid and triglycerides (TGs), but when the animals were treated with diphenhydramine (DPH), the levels of the aforementioned biochemical parameters decreased significantly (p<0.0001). The level of serum cholesterol and high density lipoprotein (HDL) was found to be reduced in Diabetes Mellitus (DM) control and when it was treated with DPH control animals, these makers increased significantly. The study done on DM and Diphenhydramine suggests that Talc increases the blood glucose level at a dose of 10mg/kg (0.14gm) and Diphenhydramine (1mg/kg)reduces the increased blood glucose level. These finding simply that diphenhydramine may be useful in the management of talc induced diabetes.
在 Wistar 大鼠中评估了滑石粉诱导的 2 型糖尿病中苯海拉明的作用。滑石粉（10mg/kg）经口给药 21 天可升高血清谷氨酸丙酮酸转氨酶（SGPT）、谷氨酸草酰乙酸转氨酶（SGOT）、血清肌酐、血糖、尿素、尿酸和甘油三酯（TGs），但当动物用苯海拉明（DPH）治疗时，上述生化参数的水平显著降低（p<0.0001）。糖尿病（DM）对照组的血清胆固醇和高密度脂蛋白（HDL）水平降低，当 DM 对照组用 DPH 治疗时，这些标志物显著升高。DM 和苯海拉明的研究表明，滑石粉在 10mg/kg（0.14gm）剂量下升高血糖水平，而苯海拉明（1mg/kg）降低升高的血糖水平。这些发现表明，苯海拉明可能对滑石粉诱导的糖尿病的治疗有用。
